L. Zhang

This study uses metabolomics to investigate how PDE inhibition affects cNMP signaling in tomato under non-stress and salinity conditions, revealing growth changes and metabolic reprogramming.

This paper develops a method to create 3D vascularized tissues using bioprinting and surgical anastomosis, showing improved viability and functionality in liver-like constructs.

This study demonstrates sub-second, multichannel neural stimulation in flies using magnetic nanoparticles and temperature-sensitive ion channels, improving the temporal resolution of magnetogenetics.

This study identifies a novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives through crystallography and mass spectrometry, revealing a unique covalent adduct formation and by-product generation.

This study shows that a bacteriophage inhibits murine norovirus replication in RAW 264.7 cells through activation of innate immune responses and guanylate binding proteins.

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

The paper identifies RLP32 as the Arabidopsis receptor for the bacterial pattern IF1, revealing its role in PTI and resistance to Pseudomonas syringae.

The paper examines circulating T cells sharing TCRs with tumor-infiltrating T cells in metastatic melanoma patients, finding they exhibit effector gene signatures similar to tumor T cells.

The paper compares metatranscriptomic responses of Arabidopsis to endophytic and pathogenic Fusarium strains, revealing transcriptional plasticity and differential gene regulation.

This study identifies a hypervirulent CRKP strain in Egypt carrying two plasmids with carbapenemase and virulence genes, highlighting the genetic basis of resistance and virulence.

The paper uses single-cell RNA analysis to compare immune cell profiles in young and old mice, finding higher proportions of effector cells in old mice that may enhance tumor defense.

This study examines genome-wide transcriptional responses of marine nematode Litoditis marina to hyposaline and hypersaline stresses, identifying conserved and specific gene expression patterns.

This study shows that stimulating soluble guanylate cyclase (sGC) with BAY41-8543 reduces skeletal and cardiac muscle dysfunction in mdx mice, suggesting sGC as a therapeutic target for Duchenne muscular dystrophy.

This study identifies EZH2's role in promoting breast cancer bone metastasis through the integrin β1-FAK pathway and TGFβ signaling.

This study shows that O-glycosylation near the furin cleavage site of SARS-CoV-2 spike protein reduces furin cleavage and is mediated by GALNT enzymes and a proline at position 681.

The paper uses synthetic TAL effectors delivered by bacteria to activate the maize gene gl3, revealing its role in cuticular wax biosynthesis and identifying downstream genes involved in this process.

The paper identifies ATF3 as a key driver of chromatin accessibility remodeling during senescence, linking it to the regulation of senescence programs.

This paper develops a CAR T cell with broad EGFR specificity to target multiple tumor clones and reduce antigen loss escape in glioblastoma.

This study shows ESD1 regulates seed setting rate in rice by controlling embryo sac development, as loss-of-function mutants exhibit reduced seed setting rates and abnormal embryo sac differentiation.

This study identifies SiCEP3, a C-terminally encoded peptide from Setaria italica, which promotes ABA import and signaling by inhibiting receptor kinase activity under abiotic stress.

The paper shows hBD-2 binds SARS-CoV-2 spike RBD and blocks viral entry into ACE2-expressing cells, with a KD of ~300 nM and IC50 of 2.4 μM.

This study shows that SflA and SflB mutants of Streptomyces coelicolor exhibit hyphal branching and ectopic DivIVA/FtsZ localization during sporulation.

The paper generates a single-cell atlas of pig lung using scRNA-seq and develops an online platform to explore lung single-cell data across species.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

The paper tracks B cells exiting germinal centers and shows they recycle through the subcapsular sinus, interacting with macrophages and returning to GCs via CCL21 gradients, supporting affinity maturation to antigenic drift.

This study shows that starvation causes E. coli to shrink its inner membrane and cytoplasm, driven by water loss, and that the Tol-Pal system is essential for recovery.