L. Zhao

The paper investigates convergent evolution of floral fragrance in self-fertilizing Capsella species, finding shared compound changes and mutations affecting scent emission.

The paper profiles global mosquito viromes across species, locations, and climates, identifies core-viruses, and links viral diversity to ecological factors and mosquito movement.

This study models ancient Eurasian selection landscapes and shows ancestry-specific genetic risk associations with modern phenotypes.

This paper identifies a microbiome guild-level signature associated with COVID-19 severity and prognosis using metagenomic analysis of fecal samples.

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

The paper identifies sex-differentially variable genes across human tissues and links them to biological functions and disease, suggesting a genetic basis and evolutionary model for sex-specific expression variability.

This study shows that the time of Chlamydia infection affects genital tract microbiome dynamics, with more robust associations in the upper genital tract.

The paper presents a near-atomic structure of the NuA4 complex and shows it has auto-inhibited conformation that becomes active upon substrate and co-factor binding.

This study compares bulk and single-cell mutational analysis to assess tumor clonal structure, finding that bulk analysis underestimates subclonal complexity and dynamic evolution.

The paper identifies Muribaculaceae family bacteria as pathobionts that induce insulin-dependent diabetes in mice through translocation to the pancreas following gut microbiota disruption.

This study develops a DNA extraction protocol (LPQ) that achieves saturated cell lysis for microbiome analysis, outperforming existing methods in detecting microbial differences.

This study characterizes fecal bacterial communities in dairy cattle across different management units, finding dynamic changes in diversity and composition.

This study shows EGCG protects against radiation-induced intestinal injury by preserving macrophages and gut microbiota, reducing inflammation and improving survival in mice.

The paper identifies two competing bacterial guilds in the gut microbiome that correlate with host health conditions and can classify multiple diseases across diverse populations.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

The paper identifies over 1000 unannotated open reading frames with protein evidence in Drosophila, revealing diverse evolutionary patterns and frequent turnover of de novo proteins.

The paper shows that hypoxia induced by pinewood nematode (PWN) loading increases tracheal elasticity and ECM thickness in beetles, enhancing PWN transmission.

This study implants graphene quantum dots in PEGylated nanoparticles to enhance in vivo imaging and tumor detection, showing improved circulation and tumor accumulation.

The paper shows that ITE, an AHR agonist, enhances PD1 antibody efficacy in a glioma model by reducing MDSCs and increasing CD8+ T cell infiltration.

This study identifies tryptamine, a gut microbiota-derived metabolite, as a contributor to insulin resistance in type 2 diabetes through TAAR1-ERK signaling.

This study identifies Ruminococcus gnavus as a gut bacterium that contributes to IBS-D by increasing serotonin biosynthesis through phenethylamine production.

This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.

This study infects neonate and adult mice with dengue virus via the nasal route, showing viral tropism and replication in multiple tissues, suggesting respiratory transmission as a potential non-vector route.

This study shows Arbidol inhibits esophageal squamous cell carcinoma growth by targeting the ATR kinase and disrupting the DNA replication pathway.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

This paper evaluates click chemistry-based methods for cross-linking peptide enrichment, finding that acid-cleavable protein-based conjugation identifies the most cross-linked peptides.

This study maps chromatin reprogramming and transcriptional regulation during hexaploid wheat embryogenesis, revealing epigenetic mechanisms governing cell fate and organogenesis.

This paper introduces SPACX, a method to profile protein conformation and interactions in living cells, revealing subcellular-specific heterogeneity and functional differences in PTEN.