Q. Li

The paper shows quorum sensing represses the Type III-A CRISPR-Cas system in S. aureus by inhibiting SarA and ArcR, which are positive regulators of the system.

This study shows that PTPMT1 deletion in skeletal muscle and heart causes metabolic inflexibility, leading to atrophy, heart failure, and death, while liver and adipose tissue deletion has no effect.

This study determines the structures of human ABCC4 in apo and complexed forms, revealing its role in exporting platelet agonists and inhibitors, and identifying a pocket for drug design.

The paper uses metagenomics to identify 22 RNA viruses in ticks from northeastern China, revealing novel species and highlighting public health risks from emerging tick-borne viruses.

This study shows that shrimp STING detects DNA to trigger an interferon-like antiviral response, independent of cGAS and involving the IRF-Vago pathway.

This study uses computational models to show that weak-rectified gap junction coupling and electrically isolated distribution of bio-pacemaker cells enhance their pacing efficiency.

This study identifies two groups of metabolites in lamprey buccal glands that modulate host responses and establishes a spatial metabolomics database for lamprey research.

This study identifies distinct molecular mechanisms for proactive and retroactive interference in Drosophila during consecutive learning tasks.

This study describes a new saurosphargid species from the Early Triassic of South China and presents a phylogenetic analysis clarifying the relationships of sauropterygians and their evolutionary history.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

The paper examines how tinamou egg coloration relates to mating signals and eco-geographical distribution, finding associations with song variables and differences in similar habitats.

This paper identifies and characterizes a novel oxidase gene cmO in Sphingomonadaceae that mediates chloramphenicol and thiamphenicol resistance through oxidative inactivation.

This study examines the effects of Salton Sea playa dust on pulmonary inflammation in mice, finding acute neutrophil inflammation similar to innate immune responses.

This study uses RNA-seq to identify molecular changes in kidney cancer among people living with HIV, finding altered expression of specific genes and pathways associated with cancer progression.

This study develops molecular markers for KTI mutant alleles in soybean using CRISPR/Cas9 to aid in breeding low TI trait cultivars.

This study shows that p53 restoration in SCLC can induce necrosis via cyclophilin-dependent mechanisms, revealing subtype-specific responses and potential therapeutic targets.

The paper identifies and analyzes non-spicular demosponge fossils from the lowermost Triassic in Armenia, proposing criteria for their recognition and discussing their evolutionary significance.

This study uses OCT imaging to show that COVID-19 causes ciliary dysfunction in nasal epithelium, including reduced cilia function and mucociliary abnormalities.

This paper screens a drug repurposing library to identify compounds that inhibit sickling in sickle cell disease, finding 106 potential anti-sickling drugs with 21 predicted to be viable oral therapies.

This paper develops a virtual liver needle biopsy method to quantify sampling bias in liver tissue, finding significant intra- and inter-needle variations in collagen proportionate area.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

This paper introduces a heat-shock protocol for wheat transformation that significantly improves efficiency using BBM-WUS, reducing the time to obtain transgenic plants to 60 days.

The paper investigates how cholesterol in a cargo membrane affects kinesin-1 binding to microtubules in the presence of tau, showing that cholesterol enhances tau's inhibitory effect.

This study investigates DNA methylation inheritance in Pacific oysters, finding that half of parental methylation differences are passed to offspring and revealing sex-specific methylation patterns linked to Rho signaling.

This paper introduces Spinning Disk Multifocal Microscopy (SDiM) for high-speed, high-resolution imaging of large biological surfaces, demonstrating its application in cortical and immune cell studies.

This study combines CODEX and RNAscope to enable simultaneous detection of proteins and RNA on single tissue sections and assesses cross-reactivity of CODEX antibodies in rhesus macaques.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.