R. Liu

This study identifies miR-132 as a critical regulator of lymphangiogenesis, showing its role in lymphatic remodelling through in vitro and in vivo experiments.

The paper introduces colorimetric and fluorescent TRAP assays for visualizing and quantifying osteoclast activity in zebrafish and medaka, showing fluorescent TRAP staining is effective and compatible with other techniques.

This study isolates a marine fungus capable of efficiently degrading polyethylene, identifying degradation products and enzymes involved in the process.

This study shows that neural crest-derived BMP7 is important for retina development and function, as its deletion leads to structural and functional abnormalities in the retina.

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

This paper engineers neuron-targeting extracellular vesicles for in utero treatment of myelomeningocele, showing improved neuroprotection and reduced apoptosis in a rodent model.

This paper develops a CRISPRi/a approach to reactivate FOXP3 and silence XIST from XCI in human breast cancer cells, showing enhanced epigenetic changes and therapeutic potential.

This study identifies 97 chemical constituents of Jing-Fu-Kang granules and reveals 531 common targets and 136 pathways involved in its mechanism for cervical spondylosis using mass spectrometry and network pharmacology.

The paper uses single-cell sequencing to analyze glioma-associated microglia and macrophages, revealing their distinct roles in tumor progression and clinical outcomes.

This study uses CpHMD simulations to analyze cysteine reactivity in kinase N-cap positions, finding that some are reactive while others are not, depending on nearby residues.

This paper introduces a cyborg brain organoid platform for long-term 3D electrophysiological recording, enabling continuous monitoring of single-cell action potentials during brain organoid development.

CODEC improves mutation detection by combining NGS throughput with single-molecule resolution, achieving similar accuracy with fewer reads.

This study uses single cell Raman-DIP to rapidly determine antimicrobial susceptibility of Elizabethkingia spp. and confirms minocycline and levofloxacin as first-line treatments.

The paper describes a method to measure mitochondrial electron transfer complexes in previously frozen cardiac tissue from offspring of exercised sows to assess exercise-induced mitochondrial bioenergetics changes.

The paper introduces a model (IsoDyn) to quantify isotopic incorporation rate and trophic discrimination, showing it provides better fits than simpler models with minimal calibration.

This paper presents a deformable microfluidic device using microbeads to separate plasma and retrieve blood cells, supported by imaging and computational modeling.

This study identifies the DEPDC1-EEF1A1-FOXO3a axis as a critical pathway promoting osteosarcoma progression by downregulating FOXO3a, with implications for therapeutic strategies.

This study identifies a sulfate-reducing bacterium that forms zero-valent sulfur through sulfide oxidation, highlighting a new pathway in the sulfur cycle.

This study identifies AGDP3 as a protein that binds H3K9me2 and facilitates ROS1-mediated DNA demethylation in Arabidopsis, revealing a mechanism linking histone modification to gene regulation.

This study develops a functionalized ECM scaffold with LXW7-DS-SILY to enhance neovascularization and diabetic wound healing in ZDF rats.

The paper examines chemical defense and tonic immobility in early life stages of Murgantia histrionica, finding eggs are more chemically defended than early nymphs, while tonic immobility is favored by hatchlings.

This paper uses spatial single-cell omics to analyze PDAC tumors and microenvironment, identifying key populations and interactions that may inform treatment strategies.

The paper isolates and characterizes a novel Chloroflexi strain, showing its role in sulfur cycling through assimilatory sulfate reduction.

This study shows that recombinant MVA vaccines expressing modified S proteins inhibit SARS-CoV-2 replication and prevent lethal disease in transgenic mice.

This study characterizes the first cultured free-living Candidatus Izimaplasma strain, revealing its unique DNA-degrading capabilities and ecological role in deep-sea methane seeps.

The paper shows Bacteroidetes are key to deep-sea carbon and nutrient cycling by degrading diverse glycans through metagenomics, isolation, and transcriptomic/metabolomic analyses.

This study identifies aglycone polyether ionophores as broad-spectrum antivirals effective against multiple enveloped viruses, including SARS-CoV-2, and demonstrates their efficacy in curing JEV-infected mice.

The paper identifies PF-3845 as a novel inhibitor of Mycobacterium tuberculosis PheRS, showing selectivity over human PheRS and potential as an antibiotic lead.

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

This study reports cryo-EM structures of the human DUOX1-DUOXA1 complex in different calcium states, revealing structural features and calcium regulation of its catalytic activity.