R. Liu

The paper shows SMIFH2 inhibits myosin ATPase activity and actin filament translocation, affecting myosin 2A, myosin 10, and other non-muscle myosins, suggesting caution in using SMIFH2 to infer formin function.

This study shows that PCK1 deficiency increases O-GlcNAcylation and promotes HCC growth under glucose deprivation by enhancing CHK2 activity.

This paper develops a lentiviral vector for β-thalassemia treatment that restores β-globin expression in Chinese patients with minimal tumorigenesis risk.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

This study uses a tumor-on-a-chip platform to show that M1 macrophages inhibit tumor growth and angiogenesis, while M2 macrophages promote tumor migration and angiogenesis through distinct molecular mechanisms.

This study investigates how neoantigen heterogeneity affects bystander immune inhibition in pancreatic cancer, finding that high neoantigen frequency is needed for effective antitumor response, which can be improved with immune therapy.

This study introduces a visible light OCTA system for human retinal imaging, achieving high-speed acquisition and microvascular oximetry with sub-100 μm vessel resolution.

This paper introduces a coupled simulation toolkit combining Geant4 and CompuCell3D to model radiation effects on tissue, enabling simulation of tumor response to radiation therapy.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

The paper reports that Heimdallarchaeota, a group of archaea, possess proteins associated with photosynthesis and may perform oxygenic photosynthesis, suggesting a photomixotrophic lifestyle.

This study analyzes DPANN archaea from deep-sea hydrothermal vents to understand their metabolism and ecological roles, revealing their genomic features and potential contributions to biogeochemical cycles.

This study identifies Schisandrin B as a potential treatment for male infertility by improving sperm count, mobility, and reproductive ability in a mouse model.

This study shows that competition between kinesin-1 and myosin-V, influenced by cortical microtubule density, determines posterior localization of osk mRNA in Drosophila oocytes.

The paper identifies ACPT gene inactivation in toothless and enamel-less mammals and estimates its inactivation times across different lineages.

This study shows SPOP promotes ubiquitination and degradation of MyD88, suppressing innate immune responses and reducing susceptibility to Salmonella typhimurium infection.

This paper develops a framework for glomerulus segmentation in kidney histopathology images using Faster R-CNN and U-Net with weakly supervised training.

This study compares the shapes and sizes of prostate lesions in dogs treated with laser, radiofrequency, and microwave ablation, finding significant differences in lesion morphology and volume.

The paper tests how changes in geomagnetic field intensity affect migration-related traits in the brown planthopper, finding responses in morphology, behavior, and physiology.

This study reports cryo-EM structures of human sGC 1β1 heterodimer in different states, revealing the structural mechanism of NO-induced activation.

This study identifies ERF109 as a regulator of auxin transport in Arabidopsis roots by directly controlling PIN2, PIN4, and PID, which are key components of auxin transport.

The paper develops a light-driven population model to examine how light-dependent life history traits of Prochlorococcus and cyanophage influence population dynamics, finding that light-dependent adsorption improves model fits but lysis saturation at high virus-to-cell ratios also plays a key role.

This paper introduces a deep learning method for label-free optical oximetry that provides uncertainty quantification and demonstrates improved accuracy over traditional methods in rat retinal imaging.

This study compares the metabolic profiles of Schistosoma japonicum in SCID and BALB/c mice to identify differences linked to developmental abnormalities in immunodeficient hosts.

This study uses untargeted LC-MS/MS to analyze chemical exposures in three workplace types, identifying how building purpose, surface materials, and location affect chemical signatures and human exposure.

The paper introduces a new two-photon microscope using a liquid crystal spatial light modulator to record neural activity in awake mice, finding heterogeneous responses in excitatory neurons across cortical layers.

The paper identifies MMR signature mutations in colorectal cancer that activate enhancers by increasing FOX factor affinity and promoting tumor growth.

This study investigates how viral lysis products affect the transcriptome of Prochlorococcus, revealing changes in tRNA abundance, nitrogen metabolism, and photosynthetic efficiency.