S. Yang

Single-cell multi-omic profiling identifies immune dysregulation in severe COVID-19, including neutrophil hyperactivation and anti-inflammatory monocytes.

This study identifies abundant and diverse circRNAs from SARS-CoV-2, SARS-CoV, and MERS-CoV, revealing a novel type of circRNA distinct from DNA-encoded circRNAs.

The paper shows that epithelial cell reintegration uses a mechanism similar to axon pathfinding, involving IgCAMs and mechanical coupling to the membrane skeleton.

The paper expands the human gut microbiome reference database by incorporating newly assembled genomes from under-represented Asian populations, improving taxonomic and functional classification and revealing associations with autoimmunity.

This study shows SATB2 drives melanoma invasion and drug resistance by inducing a neural crest mesenchyme-like transcriptional program in zebrafish and human models.

This paper introduces spatially expandable fiber-based probes for deep brain interface, enabling three-dimensional recording and stimulation of neural activity with high resolution and minimal tissue damage.

This study analyzes fungal communities in Chinese Marselan wine fermentation across regions, finding that environmental factors significantly influence fungal composition and fermentation performance.

This study identifies marrow adipogenic lineage precursors (MALPs) as critical regulators of osteoclastogenesis through RANKL expression, showing their role in both normal bone remodeling and pathologic bone loss.

This study identifies an IL1β/NFκB/ESE3 signaling axis in pancreatic stellate cells that drives fibrosis, chemoresistance, and poor prognosis in pancreatic cancer.

The paper shows HOXB13 expression is reduced or lost in neuroendocrine prostate cancer (NEPCa) and that NEPCa tumors lose prostate-specific HOX codes without gaining a clear new tissue identity.

The paper shows CYFIP2-containing WAVE complexes restrain RAC1 activation, affecting cell migration, and mutations in CYFIP2 can enhance its activity.

This study shows that targeting SCARB1 with HDL NPs in cholesterol-dependent lymphoma cells reduces GPX4, leading to ferroptosis and cell death.

The paper shows that the mitotic kinase Polo also directs cellular morphogenesis after cell cycle exit, with its activity regulated by different upstream kinases during mitosis and post-mitosis.

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

This study shows that blocking integrin αvβ8 on T cells enhances anti-tumor immunity in multiple syngeneic models and is effective even when tumor cells do not express the integrin.

This study shows that transient hyperglycemia causes long-term vascular endothelial dysfunction and delayed wound healing through DNMT1-mediated Ang-1/NF-κB pathway activation.

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

This paper adapts and evaluates a phasor-based single-molecule localization microscopy algorithm for engineered PSFs, achieving comparable precision to existing methods with improved speed.

The paper identifies the proteasome as critical for ZIKV and DENV replication through three systems biology approaches and finds proteasome inhibitors suppress both viruses.

This study identifies altered B cell subset homeostasis in IgAV patients, with increased plasmablasts and decreased specific memory B cells, correlating with IgA levels.

This paper uses a hindcast simulation to analyze biogeochemical variability in the California Current System from 1995-2010, showing how nutrient and light limitations drive productivity and how climate events like El Nino affect ecosystem states.

The paper reveals how the BBSome facilitates GPCR transport across the transition zone by extracting amphipathic helices from the inner leaflet of the membrane.

This study shows that HBV vaccines based on modified CMV vectors can clear HBV in mice through enhanced CD8+ T cell responses in both prophylactic and therapeutic settings.

This study finds that patients with heart failure have a higher risk of developing cancer compared to the general population, with increased risk observed across multiple cancer types.

This study shows that Cep57 and Cep57l1 recruit the Cep63-Cep152 complex to mother centrioles, enabling centriole duplication.

This study combines metagenomic sequencing and host response profiling to improve sepsis diagnosis by detecting pathogens and guiding clinical decisions.

This study integrates radiomic and genomic data from HNSCC patients to find associations between imaging features and genomic biomarkers, achieving moderate predictive accuracy for HPV and TP53 mutation status.

This paper introduces a rapid antimicrobial susceptibility test using laser speckle dynamics to detect bacterial growth in 2-4.5 hours.

This study shows YAP1 is increased in high-grade prostate adenocarcinoma but reduced in neuroendocrine prostate cancer, with YAP1 loss activating Wnt/beta-Catenin signaling linked to NEPC development.

The paper develops a robust CNN for diabetic retinopathy screening by addressing dataset size, data curation, and performance metrics using cloud-based methods.