T. Zhang

This study uses native mass spectrometry and structural analysis to show how copper and lipids regulate the ABC transporter MsbA, revealing a conserved KLA binding site that modulates ATPase activity.

This study determines the structure of hPRPS2 polymers using cryo-EM, revealing how ADP binding affects polymerization and catalytic activity.

This study develops an injectable hydrogel with homogenous mesenchymal stem cells to treat severe spinal cord injury in rats, showing improved functional recovery compared to intrathecal delivery.

This study investigates microbiome and short-chain fatty acids (SCFAs) profiles in rumen simulation technique (RUSITEC) systems inoculated with goat and cow rumen contents, identifying copresent microbial genomes associated with substrate degradation.

This study shows benzidine promotes bladder cancer cell proliferation via the ERK5 pathway by increasing cyclin D1 and PCNA while decreasing p21.

This study identifies a bacterial immune system that directly senses a viral capsid protein through a toxin-antitoxin system, revealing a PAMP-like mechanism for innate immunity in bacteria.

This study shows that sickle RBC-derived extracellular vesicles activate endothelial cells and enhance RBC adhesion via von Willebrand factor, with implications for SCD treatment.

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

This study compares scRNA-seq and snRNA-seq of human pancreatic islets, identifying new gene markers and three β-cell subpopulations with distinct transcriptional profiles.

This study shows that existing microbial source tracking solvers fail to solve the MST problem when ecological dynamics, such as microbial interactions and priority effects, are present.

This study identifies fermentation of macromolecules as the dominant energy source for microorganisms in gas hydrate-bearing subseafloor sediments.

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.

This study analyzes the temporal transcriptome changes in porcine macrophages infected with different ASFV strains to understand viral pathogenicity and host response dynamics.

The paper designs a DNA nanostructure for rapid, sensitive, and inexpensive detection of SARS-CoV-2 and demonstrates its potential to inhibit viral infection.

The paper shows TIR domains catalyze ADP-ribosylation reactions to produce signaling molecules that specifically activate the EDS1-SAG101-NRG1 immunity branch in plants.

The paper investigates two filament structures of E. coli PRPS resolved by Cryo-EM, revealing how ligand binding modulates allosteric inhibition and PRPP production.

This study identifies m6A modification patterns and functions during sexual reproduction in Chlamydomonas reinhardtii, showing its role in regulating microtubule-based processes.

The paper shows that differences in peptide binding between chicken MHC class I alleles BF2*1901 and BF2*1501 explain their differing susceptibility to Mareks disease.

This study edits the MeSWEET10a promoter in cassava to confer resistance to bacterial blight without affecting yield traits.

This study identifies TraB1 as a novel EMCS component in Arabidopsis that regulates both ER-mitochondrial tethering and mitophagy, essential for mitochondrial function and stress recovery.

This study uses scRNA-seq to identify metabolic reprogramming in human colonic immune cells across locations and ulcerative colitis states, linking metabolism to immune function and treatment resistance.

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

This study identifies the APC/CTAD1-WL1-NAL1 pathway as a regulator of leaf width in rice and shows that mutations in WL1 lead to leaf width variation.

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

This study determines the structure of Drosophila P5CS filament, revealing how filamentation coordinates GK and GPR domains for catalysis.

This paper develops a RHAMMB-targeting nanoparticle delivering siBcl-xL and KLA peptide to treat PNETs, showing synergistic tumor reduction in mice.

This paper develops PRPK-directed phthalimides based on pomalidomide, identifies a potent and selective PRPK binder, and highlights distinct binding mechanisms compared to cereblon.

The paper identifies consistent predictors of microbial community composition across grassland scales, finding low context-dependency and predictable variation linked to productivity.