X. Chen

This study maps spatial immune cell composition in human TB lung tissue, revealing diverse non-necrotizing aggregates surrounding necrotizing granulomas.

The paper identifies ID1 as an autonomous phosphate regulator that modulates the miR399-ZmPHO2 signaling module to maintain Pi homeostasis in maize.

The paper identifies a fungal effector that enhances RPW8.2 nuclear localization and transcription, boosting immunity in Arabidopsis against powdery mildew.

This paper engineers MAIT cells with CARs to target cancer cells, showing comparable cytotoxicity to CD8+ CAR-T cells but with lower IFN-γ expression.

This study shows honeybees use the waggle dance to obtain both a flying direction and a map-like coordinate system to locate food sources.

This study identifies mce3R mutations causing contezolid resistance in Mycobacterium tuberculosis by increasing Rv1936-mediated drug degradation.

This study investigates how Oreorchis patens responds to cold stress by analyzing physiological, biochemical, and molecular mechanisms, identifying differentially expressed genes and confirming their roles through qRT-PCR.

The paper introduces PRM-SRS imaging to visualize and identify multiple lipid species in cells and tissues with high chemical specificity and subcellular resolution.

The paper identifies potassium homeostasis as essential for medulloblastoma maintenance using a novel transposon system in mice and human samples.

This study examines age-related changes in vitellogenin vesicles and yolk organelles in C. elegans, finding significant expansion and fusion of these structures in post-reproductive worms.

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

This study shows that asparagine restriction induces a biphasic response in CD8 T cells, enhancing their metabolic fitness and antitumoral function through ATF4/NRF2-dependent mechanisms.

This study shows that osteocyte ablation in mice leads to senescence-associated changes in bone and bone marrow lineages, causing sarcopenia, osteoporosis, and shortened lifespan.

The paper identifies the re-emergence of SADS-CoV in pigs in Guangxi, China, through qPCR and metagenomic analysis, suggesting undetected circulation since 2019.

This study shows that kynurenic acid reduces A1 astrocyte activation and promotes A2 astrocyte formation, improving cognitive deficits in HIV-1 gp120 transgenic mice.

The paper proposes updated nomenclature for plant ribosomal protein genes to improve adoption in plant biology, extending previous systems to include organellar ribosomes and additional species.

The paper identifies SNULs, noncoding RNAs that form nucleolar territories on NOR chromosomes and regulate rRNA expression by influencing pre-rRNA sorting and processing.

This study develops an injectable hydrogel with homogenous mesenchymal stem cells to treat severe spinal cord injury in rats, showing improved functional recovery compared to intrathecal delivery.

The paper identifies a fibrogenic macrophage subset linked to liver and lung fibrosis across species and shows that targeting specific cytokines reduces fibrosis in models.

This study shows that neutrophils in tuberculosis promote pathologic hematopoiesis by producing G-CSF, which impairs T-cell immunity through IFNAR1 signaling.

This study identifies Carmn, a SMC-specific lncRNA, as critical for maintaining GI smooth muscle contractile function and motility, with loss of function leading to impaired contractility and pseudo-obstruction.

This study identifies Arabidopsis AAR2 as a conserved splicing factor that also promotes miRNA biogenesis by interacting with HYL1 and regulating its dephosphorylation.

This study isolates and characterizes a novel inovirus, {phi}AFP1, from Alteromonas abrolhosensis, revealing its impact on host metabolism and motility through transcriptomic analysis.

This study identifies a novel endolysosomal trafficking pathway in Magnaporthe oryzae that facilitates effector secretion and host invasion via Rab7/Retromer/MoSnc1-mediated vesicle transport.

This study characterizes the biased agonism of CXCR4 and CXCR7, revealing differences in G-protein coupling, β-arrestin recruitment, and ERK1/2 activation.

The paper introduces A-PoD, a deconvolution algorithm for super-resolution SRS imaging, achieving 52 nm resolution and enabling nanoscopic analysis of biomolecules and metabolic dynamics.

The paper develops bacterial Vm sensors to study Vm dynamics and shows that excitable states enhance antibiotic tolerance.

The paper identifies miRNA targets in maize using PARE datasets, revealing tissue-specific cleavage and new miRNA-target pairs involved in seed germination.

This study identifies a common mechanism for temperature sensing in TRPM8 and TRPV1 thermoTRP channels through water-protein interaction changes.

MADET is a manually curated database that compiles 453 microbiota-drug associations from 24 papers to aid in understanding microbiota's role in anticancer drug efficacy and toxicity.