X. Chen

This study develops a deep learning method for microbubble localization in ultrasound imaging, showing improved accuracy and performance in vivo.

This study shows that LDH isoenzymes regulate T cell glycolysis and differentiation by maintaining optimal metabolic conditions.

This study maps 3D genome reorganization during skeletal muscle stem cell activation, proliferation, and aging using Hi-C, revealing how chromatin architecture influences gene expression and lineage progression.

The paper shows host APOBEC3A, APOBEC1, and APOBEC3G edit SARS-CoV-2 RNA, promoting viral replication and suggesting APOBEC-mediated mutations contribute to viral evolution and new strain emergence.

This study shows that UTX promotes glioblastoma progression by upregulating periostin expression, and its knockdown inhibits tumor growth and promotes apoptosis.

This paper uses deep learning to segment 15 intracellular compartments from super-resolution images with one dye, achieving high accuracy and faster imaging.

This study examines how mechanical ventilation impacts the respiratory tract microbiota in rats, finding increased biofilm formation and dispersed microbial clustering.

This paper develops a RHAMMB-targeting nanoparticle delivering siBcl-xL and KLA peptide to treat PNETs, showing synergistic tumor reduction in mice.

This study shows that Serum Amyloid A (SAA) worsens acetaminophen-induced liver injury by damaging sinusoidal endothelial cells and increasing platelet aggregation.

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

The paper investigates human-specific CD33 mutations linked to cognitive protection and Alzheimer's disease resistance, linking them to evolutionary pressures and immune evasion.

This study shows that Ser68 phosphorylation is essential for CENP-A deposition, centromere function, and mouse viability.

The paper develops a causal framework to identify tumor-specific intercellular communication networks in head and neck squamous cell carcinoma, revealing subtype-specific patterns linked to clinical outcomes.

The paper examines postmating transcriptional responses in Drosophila species to test the coevolutionary divergence model, finding divergent gene expression and disrupted profiles in heterospecific matings.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

This study shows ligand binding causes intracellular conformational changes in monomeric EGFR, linking extracellular and intracellular regions through the transmembrane helix.

This paper identifies a novel pectin from Syzygium aromaticum that strongly inhibits SARS-CoV-2 replication by binding to 3CLpro, PLpro, and RdRp enzymes.

This study shows that Pparg promotes luminal differentiation and tumor formation in urothelial cells, with tumors showing immune desertion and potential subtype shifts over time.

The paper identifies membraneless organelles in bacteria that enhance stress tolerance through liquid-liquid phase separation.

This study develops a human hepatic organoid model of ARPKD liver fibrosis, showing that the ARPKD mutation leads to fibrosis through TGFβ and PDGFRB pathways.

This study shows that type IV pili in bacterial consortia reduce spatial intermixing, forming a bubble-jet pattern that affects community productivity.

This study shows AMPK and UPR interact via a positive feedback loop in muscle cells exposed to palmitate, with AMPK agonists enhancing UPR gene expression.

The paper shows that RZ-1 and PRC2 work together to silence NCED6, a gene involved in ABA biosynthesis, which is essential for seed germination in Arabidopsis.

This study shows PBP1 in Staphylococcus aureus has essential roles in cell division through its enzymatic activity and PASTA domains, affecting septum formation and morphology.

This study shows macaque monkeys use strategy-based hierarchical decision-making to play Pac-Man with over 90% accuracy, revealing advanced cognitive capabilities previously unobserved in animals.

This paper introduces Deep-SMV, a deep learning-based method for super-resolution microbubble velocimetry that directly outputs blood velocity maps without requiring microbubble localization.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

The paper identifies mosaic evolution in multiple beta-barrel porin genes in E. coli, showing local recombination and sequence variation that may help bacteria evade environmental threats.

This study shows that Malus baccata contributes to the genomes of cultivated European and Chinese apples through gene flow, alongside Malus sylvestris and Malus sieversii.

This paper shows that glycosaminoglycans (GAGs) reduce long-range mechanical communication between cells in collagen networks by preventing collagen fiber alignment.