X. Fan

This study shows metformin reduces high glucose-induced endothelial ROS through the AMPKα-Lin-28-OGG1 pathway in HUVECs and diabetic mice.

This paper introduces GETMap, a method to determine tissue origin of plasma DNA carrying genetic variants, validated across prenatal testing, transplantation, and oncology scenarios.

This study shows the SARS-CoV-2 D614G variant has enhanced replication and transmissibility in animal models, explaining its global dominance.

This study shows that SARS-CoV-2 structural stability decreases with temperature, supporting the seasonal pattern of viral infectivity.

This study finds that cutting sugarcane at 5 cm depth increases root fresh weight, volume, and fine root development, leading to higher cane yield compared to 0 or 10 cm cutting depths.

This study shows that repopulating Kupffer cells in adult mice originate directly from hematopoietic stem cells, not from preexisting Kupffer cells or monocytes.

This study analyzes immune responses in COVID-19 patients using single-cell RNA sequencing to identify differences in immune cell behavior across disease severity stages.

The paper identifies monocyte subsets with high osteoclastogenic potential and shows IRF8 regulates their epigenetic and transcriptional programs.

This study demonstrates that indocyanine green (ICG) emits strong NIR-IIb fluorescence when dissolved in protein solutions, enabling high-resolution bioimaging with improved signal-to-background ratio.

This study examines how environmental factors and landscape heterogeneity influence genetic structure in wild rice Zizania latifolia across a latitudinal gradient in China.

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

This paper presents a microfluidic ELISA technology for rapid, quantitative, and sensitive detection of SARS-CoV-2 biomarkers in small sample volumes.

This paper presents full-length transcriptome data of Ascosphaera apis mycelium and spore using PacBio SMRT sequencing, providing high-quality transcripts for genome and transcriptome annotation improvements.

Click-ExM expands super-resolution imaging to all biomolecules by integrating click-labeling into expansion microscopy.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

This study examines how social support moderates the relationship between role conflicts and job satisfaction among nurses with multiple roles in China.

This paper introduces a method for preparing high-yield monolayer graphene cryo-EM grids that improve resolution and protein density for cryo-EM studies.

This study uses single particle cryo-EM to determine the structure of 52 kDa streptavidin at 3.2 Angstrom resolution, demonstrating the feasibility of high-resolution imaging for small molecules.

The paper shows nuclear actin enhances RNA polymerase II clustering during inducible transcription, facilitating rapid gene expression in response to stimuli like serum and interferon-gamma.

This paper develops a portable 2D gas chromatography device with machine learning to diagnose ARDS from breath samples, achieving 87.1% accuracy.

This study shows that delivering a RyR2-targeting nanobody via AAV9 improves cardiac function in rat models of ischemic heart failure by reducing calcium leak and reversing dysfunction.

This paper identifies ER-associated Drp1 oligomers formed via Mff and shows their role in mitochondrial division.

The paper demonstrates the use of Volta phase plate with Cs-corrected TEM to achieve near-atomic resolution structures of apo-ferritin from over-focused images.