X. Zhao

This study shows that mitochondrial dysfunction caused by Lrrk2G2019S promotes non-pyroptotic cell death via GSDMD and increases susceptibility to infection.

The paper shows that megakaryocytes generate large numbers of platelets intravascularly in the lung, dependent on oxygenation, endothelium, and TPM4.

This study examines beetle evolution through the end-Permian mass extinction, showing xylophagous beetles declined due to forest collapse and later rebounded with forest recovery.

This study identifies FOXP4 as a regulator of beige adipocyte differentiation and thermogenesis, showing it suppresses thermogenic potential in preadipocytes but enhances it in mature adipocytes.

This paper designs novel membrane receptors with enhanced activity and stability through engineered allosteric networks involving solvent-mediated interactions.

This study shows that loss of ACKR4 in colorectal cancer cells impairs dendritic cell migration and T-cell priming, leading to immune checkpoint blockade resistance.

The paper investigates how genetic variants in the ACE2 gene affect susceptibility to SARS-CoV-2 infection by analyzing their impact on viral entry.

This study evaluates the neutralizing activity of ZF2001 vaccine-elicited antisera against SARS-CoV-2 variants, finding that E484K/Q mutations reduce neutralization and that extended intervals between doses improve variant resilience.

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

This study identifies B1-type cyclins' role in microtubule organization during Arabidopsis cell division, showing their importance in mitotic networks and interactions with GIP1.

The paper introduces ultraID, a compact and efficient biotin ligase for proximity-dependent biotinylation, demonstrating its use in probing interactomes with high temporal resolution.

A strain-programmable bioadhesive patch accelerates wound closure and healing in diabetic mice and human skin.

The paper identifies a Nup358 helix that transitions to an α-helix upon BicD2 binding, facilitating dynein recruitment and processive motility.

This paper introduces BATTLES, a high-throughput method that applies biomechanical force to screen pMHCs for T-cell activation, revealing force- and sequence-dependent responses.

This study identifies and characterizes brevibacillin 2V, a novel antimicrobial lipopeptide with low hemolytic activity against eukaryotic cells, showing promise for antibiotic development.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports the origin of eukaryotes within Archaea.

This study examines how acute isolation affects vocal and non-vocal social behaviors in male and female mice during same-sex and opposite-sex interactions, finding stronger effects in females.

An off-the-shelf bioadhesive patch is introduced for facile sutureless repair of gastrointestinal defects, addressing various limitations of conventional suture-based treatments.

The paper shows that morphogenesis in multi-layered tissues is self-organized by interfacial mechanical interactions that create compression gradients, leading to stratification or 2D morphogenesis depending on tissue fluidity.

This study shows SARS-CoV-2 entry into host cells relies on clathrin-mediated endocytosis and phosphoinositides, with ACE2's cytoplasmic domain and enzymatic activity not required for this process.

This study shows sulfur limitation increases duckweed starch yield without reducing growth, making it a promising method for biofuel production.

The paper presents the cryo-EM structure of the human Nav1.5-E1784K variant and identifies a mutational hotspot in fast inactivation segments linked to LQT3.

This study shows ARGONAUTE10 maintains miRNA gradients to regulate cell fate and division in Arabidopsis root meristems, preventing ectopic xylem formation.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports a 2-domain tree of life by showing Tyrarchaeota as a deeper branching lineage than Heimdallarchaeota.

This study shows that SHARPIN is essential for platelet linear ubiquitination and function, particularly in responses to CRP and U46619, with impaired thrombosis in SHARPIN-deficient mice.

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.

This paper develops a barnacle-inspired hemostatic paste that rapidly seals tissues by repelling blood with a hydrophobic matrix and crosslinking with tissues under pressure.

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

The paper examines how autophagy and mitochondrial fission impact the Harderian gland in male hamsters under different photoperiods, finding autophagy levels correlate with gland weight changes.

This study identifies the transferrin receptor (TfR) as an additional receptor for SARS-CoV-2 entry, showing that TfR-mediated infection can occur independently of ACE2 and that targeting TfR has anti-viral effects.