Y. Chen

This paper investigates retinal energy metabolism, revealing that photoreceptors use distinct metabolic pathways, including the mini-Krebs, Cahill, and Cori cycles, to uncouple glycolysis from oxidative phosphorylation.

This study identifies epsin-2 as a therapeutic target for multiple system atrophy by regulating FABP7/-synuclein hetero-aggregates propagation.

The paper identifies bacteriophage nucleotidyltransferases and anti-TIR defense genes that inhibit TIR-STING immune responses to promote viral propagation.

The paper identifies a conserved membrane protein that negatively regulates Mce1 complexes in mycobacteria by inhibiting transporter assembly.

This paper develops a virtual liver needle biopsy method to quantify sampling bias in liver tissue, finding significant intra- and inter-needle variations in collagen proportionate area.

This study identifies how SARS-CoV-2 S protein inhibits type I interferon signaling by interacting with and reducing phosphorylation of STAT1/STAT2, preventing ISGF3 complex formation and ISG expression.

The paper shows that TIN1, an ER stress-induced protein in Arabidopsis, is selectively degraded by the ERAD complex during stress recovery, while other UPR-induced proteins remain stable.

This study uses single-cell RNA sequencing to show that aged alveolar macrophages exhibit a senescence-like phenotype linked to reduced CBFβ expression and impaired self-renewal.

This study uses iterative transcription factor screening to generate microglia-like cells from human iPSCs, identifying a combination of TFs that efficiently differentiate iPSCs into microglia-like cells within 4 days.

This paper identifies synthetic lethality between PRC2 inactivation and DNMT1 inhibition in MPNST, showing enhanced cytotoxicity through retrotransposon activation and innate immune signaling.

This study shows that PRC2 inactivation in tumors creates an immune-desert microenvironment, leading to resistance to immunotherapy and suggests strategies to reverse this effect.

The study identifies the wheat locus P2, associated with elongated glumes, as mapping to chromosome 6A and linked to ectopic expression of SVP-A1.

This study uses single-cell RNA sequencing to analyze shrimp hemocytes, revealing evolutionary parallels between invertebrate and vertebrate myeloid cells.

This study identifies a toxin-mediated policing system in Bacillus that punishes phenotypic cheaters, enhancing population fitness in plant rhizosphere and under stress.

The paper reports the in situ structure of SARS-CoV-2 Delta variant virions and captures membrane fusion snapshots, revealing unique architectural features and fusion mechanisms.

This study uses scRNA-seq and scTCR-seq to analyze virus-specific CD4+ T cells during chronic LCMV infection, identifying distinct transcriptional states and clonal diversity.

This study identifies three molecular subtypes of synovial sarcoma through multi-omics analysis, linking BAF complex alterations to tumor evolution and clinical outcomes.

This study shows that Varroa destructor mites vector Deformed wing virus (DWV) with varying efficiency depending on their phoretic stage and the DWV type they transmit, with DWV-B reducing mite lifespan.

This study shows EGCG protects against radiation-induced intestinal injury by preserving macrophages and gut microbiota, reducing inflammation and improving survival in mice.

This paper introduces Wolffia australiana as a model system for studying plant morphogenesis using a Plant-on-Chip culture system and advanced technologies like snRNA-seq.

The paper shows that waterbird community composition strongly predicts HPAI H5 occurrence in wild birds across different epidemics, with similar patterns observed for H5N8 and H5N1.

This study compares antibody neutralization efficacy against SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, BA.2, and BA.3, showing increased resistance and the benefit of vaccine boosters.

This paper identifies an Acidobacterium that produces diverse brGDGTs and shows temperature primarily controls C5-methylation while cyclization is influenced by multiple factors.

This study evaluates the impact of R328 mutations on NGLY1 activity using an in vitro assay, identifying dysfunctional, similar, and decreased activity mutations.

This paper introduces a heat-shock protocol for wheat transformation that significantly improves efficiency using BBM-WUS, reducing the time to obtain transgenic plants to 60 days.

This study shows that M2 macrophage-derived extracellular vesicles reduce cytokine storm by targeting multiple pathways and can act as nanodecoys against SARS-CoV-2.

This study examines the evolution of bacterial signaling complexity in Campylobacterota, showing increases during niche expansion and decreases during specialization.

This paper develops a machine learning surrogate model to rapidly quantify uncertainty in cerebral circulation simulations, enabling real-time risk assessment of cerebral hyperperfusion after carotid artery stenosis surgery.

This study edits the MeSWEET10a promoter in cassava to confer resistance to bacterial blight without affecting yield traits.