Y. Chen

This study identifies YTHDF1 as an oncogenic m6A reader promoting AML by enhancing oncogenic translation and shows tegaserod inhibits its function.

This study identifies MRC's organ-specific roles in regulating starch granule initiation in wheat leaves and endosperm, showing it promotes leaf granules but delays endosperm B-type granule initiation.

This study identifies Rap1's role in coordinating cell-cell adhesion and cytoskeletal reorganization during collective cell migration in Drosophila embryos.

The paper identifies three Pseudomonas putida isolates with diverse pentose catabolism capabilities and characterizes their genes and pathways for xylose and arabinose oxidation.

The paper uses FRET nanosensors to study lactate and glucose metabolism in retinal Müller cells, revealing MCT2 and MCT4 expression and metabolite flux dynamics.

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

This study identifies distinct in vivo properties and functions of large and small extracellular vesicles in breast cancer, showing their differential biodistribution and tumorigenic potential.

This study compares transcriptomic and metabolomic responses to drought in two switchgrass genotypes, identifying specialized diterpenoids as key to drought tolerance.

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

This study examines how socioeconomic status across the life course affects BMI trajectories and obesity risk in China using longitudinal data from the China Health and Nutrition Survey.

The paper identifies independent hard selective sweeps in two Colorado potato beetle populations linked to insecticide resistance, suggesting rapid and repeated adaptation to pesticides.

This study compares epigenomic and transcriptional changes in active and latent HIV-1 infection of SupT1 cells, finding broader alterations in latent infection affecting both protein-coding and long non-coding RNAs.

This study uses a yeast-based system to identify nirmatrelvir-resistant mutations in SARS-CoV-2 Mpro and confirms findings with structural analysis.

The paper investigates the combined effects of eight heavy metals on Bacillus cereus, revealing global iron starvation responses not observed with individual metals.

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

The paper identifies redundant medium components in iPSC differentiation to microglia using single-cell RNA sequencing and provides an optimized protocol for generating functional microglia.

This study identifies EFNA4 amplification as a driver of lung adenocarcinoma lymph node metastasis through genomic analysis and functional experiments.

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

This study identifies mce3R mutations causing contezolid resistance in Mycobacterium tuberculosis by increasing Rv1936-mediated drug degradation.

This study shows tegaserod maleate inhibits gastric cancer growth by targeting MEK1/2 in vitro and in a mouse model, with effects comparable to trametinib.

The paper characterizes the genomic and transcriptomic landscape of MDA PCa PDX models and develops an organoid platform to study prostate cancer heterogeneity and resistance.

The paper develops ACE2-Fc molecules that neutralize SARS-CoV-2 and show Fc-effector activity, effectively treating lethal infection in mice.

The paper analyzes aging and cancer by profiling ubiquitinome and RNA-seq data in mice, identifying H2A ubiquitination as a marker linked to prognosis and tumor microenvironment.

The paper tests if phylogenetic conservatism improves seed germinability prediction models in shortgrass prairie species and finds it does not.

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

This study shows metformin reduces arthrofibrosis in rats by altering fibroblast metabolism, shifting it from oxidative phosphorylation to aerobic glycolysis.

This paper develops a method using chiral derivatization and TIMS-MS to separate and visualize 19 pairs of chiral amino acids in complex biological samples.

This paper demonstrates a method to distinguish and quantify chemically similar small molecules using electrochemical aptamers by tuning surface charge.

The paper identifies a latitudinal gradient in plant leaf-associated bacterial communities, showing host-driven selection at high latitudes and multiple factors at low latitudes.

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.