Y. Chen

The paper identifies CFS1 as an autophagy adaptor that connects autophagosomes with the ESCRT-I component VPS23 to form amphisomes, facilitating vacuolar delivery in plants.

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

This paper introduces an argonaute-facilitated PCR platform that improves PCR sensitivity by using MejAgo to enhance guide DNA/template pairing, eliminating the need for an annealing step.

This study shows that HIV-1 Vpu reduces nnAb recognition and ADCC resistance, with nnAb Fc-effector functions dependent on Env's open conformation.

This study shows that combining fecal microbiota transplantation with anti-PD-1 therapy improves survival and tumor control in mice, with specific gut bacteria and metabolites contributing to the enhanced efficacy.

This study compares Reelin+ HSCs and Desmin+ HSCs in liver fibrosis using fate tracing, showing differences in activation, migration, and proliferation in response to cholestatic and hepatotoxic injuries.

VE607 inhibits SARS-CoV-2 infection by stabilizing the RBD in the 'up' conformation and blocking S-ACE2 interaction across multiple variants.

This study shows that Cdk11 promotes centromeric transcription to maintain cohesion during mitosis by phosphorylating RNAPII.

This study identifies FOXM1 as a transcription factor that specifies and loads chromatin DNA fragments into extracellular vesicles via an LC3-dependent autophagosome-MVB pathway.

This study creates ECM models with varied topology, composition, and stiffness to study their impact on cellular phenotypes, showing EMT shifts are multidimensional and not solely dependent on single ECM features.

This study examines the P132H mutation in Omicron SARS-CoV-2 Mpro, finding it reduces thermal stability without affecting catalytic activity or drug inhibition.

This study identifies ACE2 as the receptor for NeoCoV and PDF-2180-CoV, two close MERS-CoV relatives in bats, showing they can use bat ACE2 and, with mutation, human ACE2.

This paper evaluates the temporal evolution of green development in Baoshan, Yunnan Province, using statistical models to analyze trends, subsystem interactions, and influencing factors.

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

The paper determines the asymmetric homodimer structure of mouse pendrin using cryo-EM, revealing its electroneutral anion exchange mechanism and pathogenetic mutation properties.

The paper develops HypDB, a database of proline hydroxylation sites, and identifies functional roles and biomarkers through proteome analysis.

This study shows Epac1 regulates SUMOylation by forming nuclear condensates in response to cAMP, linking stress responses to SUMOylation dynamics.

This study identifies HMGN5 as a novel epigenetic target in breast cancer by showing it promotes tumorigenesis through STAT3-mediated chromatin regulation and suggests siRNA-based therapy.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

This study identifies PBP2 as the primary target of cephalosporins in C. difficile and reveals a unique Zn2+-binding motif in PBP2 and related PBPs that contributes to cephalosporin resistance and sporulation.

This study identifies VRK1 as a synthetic lethal target in VRK2-methylated glioblastoma by showing that VRK1 inhibition leads to tumor growth inhibition in xenograft models.

This study shows that homologous or heterologous boosters of inactivated vaccines increase neutralizing antibodies against SARS-CoV-2 Omicron, reducing escape from neutralization.

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

This study constructs a pan-vaccine (S6) based on the evolutionary patterns of SARS-CoV-2 spike protein to combat diverse variants, showing broader neutralization than existing vaccines.

This study shows that increased temperatures disrupt meiotic stability in autotetraploid Arabidopsis by interfering with chromosome pairing and crossing-over.

The paper shows TRPV4 activates TMEM16F in trophoblasts, promoting cell fusion, and identifies this as a mechanism for syncytialization and disease-related fusion.

The paper shows that minor intron splicing efficiency increases in castration-resistant prostate cancer and that inhibiting the minor spliceosome reduces tumor burden.

The paper identifies a short prokaryotic argonaute (pAgo) in Sulfolobus islandicus that, along with Aga1 and Aga2, provides antiviral defense through abortive infection.

This study identifies a novel kidney regeneration mechanism triggered by physiological stress, involving macula densa cells controlling progenitor cells through secreted factors.

The paper identifies the macula densa cells in the kidney as neuron-like structures with functions similar to interoceptive neurons, regulating organ functions through local neural networks.