Y. Liu

The paper develops a library-based platform to identify optimized chimeric antigen receptors (CARs) with improved anti-tumor functions through high-throughput screening of diverse signaling domains.

The paper screens a fragment-based library to identify inhibitors of Lassa virus endonuclease, finding two benzotriazole compounds that inhibit viral minigenome activity and show synergistic antiviral effects.

This study develops a Newcastle disease virus-based vaccine expressing a prefusion-stabilized SARS-CoV-2 spike protein, showing strong immune responses and cross-neutralization against variants in mice and hamsters.

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

The paper identifies ProXs, proteins capable of forming membraneless organelles in plants, and shows their conservation across species.

This paper demonstrates that annealing the 70S ribosome at a fast cooling rate synchronizes it into a minimum-energy conformation, enhancing homogeneity and stability for structural analysis.

AFEchidna is an R package that simplifies genetic analysis in breeding datasets by implementing mixed linear models for variance components and BLUP predictions.

This study uses CRISPR/Cas9 ribonucleoproteins delivered via particle bombardment to edit the wheat genome, resulting in a 10% reduction in culm length without yield loss.

This study shows that Urocortin3 in the MePD mediates psychosocial stress-induced suppression of LH pulsatility and CORT release in female mice.

This study examines right ventricle remodeling in tail-suspended rats under microgravity simulation, finding STAT3 accumulation and gap junction remodeling without significant hypertrophy.

The paper introduces a method to visualize two endogenous chromatin loci in living cells using synthetic zinc-finger proteins and frankenbodies, revealing their dynamic association and separation upon cohesin disruption.

This study shows that BCL6 helps cancer cells survive genotoxic stress by repressing PTEN and enhancing interferon responses, suggesting BCL6 inhibition could improve cancer treatment.

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

This study shows that RANKL from bone marrow adipocytes regulates trabecular osteoclast formation and bone loss in mice, with implications for therapeutic targeting of bone marrow adiposity.

This study uses molecular dynamics simulations to show how RND1 and RhoD GTPases differentially affect plexin dimerization through distinct membrane interactions.

This study shows MKP-1 modulates TRAF6 ligase activity by regulating DUBs, leading to altered ubiquitination and phosphorylation in TLR signaling.

The paper identifies a dual-reactive TCR that recognizes HIV-1 epitope Gag TL9 presented by both HLA B*81:01 and B*42:01, showing enhanced control of viral infection through structural and functional analysis.

This study screens botanical drugs against SARS-CoV-2 entry and identifies four compounds that inhibit viral entry and show synergy with remdesivir.

The paper identifies the biosynthetic pathway of nemamides in C. elegans, revealing a novel mechanism for intermediate trafficking between PKS and NRPS systems.

This study uses CEST MRI to detect antiretroviral drugs in the CNS, showing linear correlation between drug concentration and CEST effects.

This paper identifies and characterizes a phage-derived depolymerase, Dpo71, which enhances antibiotic efficacy and immune response against multidrug-resistant Acinetobacter baumannii.

The paper presents 37 new genomes of haloarchaeal tailed viruses, expands their classification into 14 families, and explores their evolution and ecological distribution.

This study shows non-English-language science provides crucial evidence for global biodiversity conservation, expanding geographical and taxonomic coverage but often with less robust study designs.

This study shows that Tmem138 is essential for rhodopsin transport across the photoreceptor connecting cilium and outer segment biogenesis, with its absence causing photoreceptor degeneration.

This paper identifies and characterizes a gene cluster in barley responsible for producing diterpenoid phytoalexins in response to fungal infection.

The paper reports chemical shift assignments for 12 RNA hairpins to enhance the BMRB database.

This study deletes SOD2 in skeletal muscle of adult mice and finds no major metabolic impairment but altered lipid metabolism and mitochondrial abundance.