Y. Liu

This study identifies a novel Arf1 binding site on WRC that drives activation through a mechanism distinct from Rac1.

This study develops a stable and safe mRNA vaccine (cmRNA-1130) using degradable lipid nanoparticles against the SARS-CoV-2 Delta variant, showing potent immune responses and stability.

This paper develops a bispecific antibody that targets both RBD and S2 of SARS-CoV-2, showing improved neutralization against Omicron and other variants compared to its parental monoclonal antibodies.

This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.

The paper reports WAVE Regulatory Complex structures bound to Rac1, revealing how Rac1 binding at the A site activates WRC to drive actin polymerization.

The paper models how adversarial interspecies relationships can enhance gene drive suppression in spatially structured populations, showing both benefits and risks for population elimination.

The paper identifies ATM and KEAP1 as targetable vulnerabilities in solid tumors through a CRISPR metabolic screen revealing their synthetic lethality.

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

This study identifies a chitin-binding protein, CgCBP, highly expressed in the outer fold of the mantle of Pacific oyster Crassostrea gigas, which is linked to shell pigmentation through its role in periostracum structure.

This study develops GlycoID tools to track O-GlcNAc-modified protein hubs with spatiotemporal control, revealing functional changes during signaling events like insulin stimulation.

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

This study identifies bZIP25 and bZIP53 as transcription factors regulating pavement and trichome cell development in Arabidopsis thaliana using single-cell RNA-sequencing.

This study evaluates the use of the housekeeping gene gyrA as a molecular marker for Bacillus species diversity and ecology, showing improved resolution compared to 16S rRNA.

This paper develops an ultra-high-throughput method for microbial single-cell whole genome sequencing to study microbial dark matter and improve metagenomic analysis.

This study identifies and characterizes cancer-associated fibroblasts (CAFs) in glioblastoma using single-cell RNA sequencing and spatial transcriptomics, revealing their functional roles in tumor progression and microenvironment interactions.

This study shows Sus1 regulates yeast lifespan by linking transcription to mRNA export through the TREX-2 complex, with mRNA export factors rescuing lifespan defects in sus1 mutants.

This paper identifies the AMPK-p38 signaling axis as a pathway to convert primed human pluripotent stem cells to the naive state using AICAR or CA-p38.

This study identifies WDR5 as an epigenetic regulator that promotes breast cancer growth and metastasis through KMT2-independent translation regulation, suggesting therapeutic strategies targeting WDR5.

The paper determines the solution structure of NPSL2, an RNA element regulating miR-17~92a processing, revealing its hairpin structure and pH-sensitive features.

The paper shows that phase-separated TRB proteins aggregate with PRC2 to enhance Polycomb silencing in plants.

The paper examines urinary proteomic changes before and after QIV and COVID-19 vaccination, finding immune-related pathway enrichment and suggesting prior exposure to coronaviruses.

The paper sequenced full-length transcriptomes of four reef-building corals to uncover molecular mechanisms of calcification, symbiosis, and circadian genes.

The paper tests a trivalent NDV-HXP-S vaccine against SARS-CoV-2 variants in mice, showing increased protection and cross-neutralizing antibodies against Omicron.

The paper describes a Cambrian fossil with features of multiple lophophorate phyla, suggesting an intermediate evolutionary position between Phoronida and Brachiopoda.

This paper develops a Cas9-RNAi RNP tool that combines RNAi and CRISPR for simultaneous gene knock out and knock down, and enhances homology-directed repair.

This paper develops two CRISPR-based systems for genetic manipulation in Acidithiobacillus ferridurans, achieving efficient gene knockdown and genome editing with significant effects on sulfur and iron metabolism.

This study uses Restricted Boltzmann Machines to analyze SELEX data for thrombin aptamers, enabling sequence fitness estimation, classification, and novel molecule generation, which is validated experimentally.

This study examines the evolution of bacterial signaling complexity in Campylobacterota, showing increases during niche expansion and decreases during specialization.

The study evaluates algae community distribution in the Hulanhe Wetland, finding that TN and TP are key environmental factors influencing algae composition.

This study investigates the functional roles of OsCKX genes in rice by generating mutants, revealing functional overlap and subfunctionalization, and identifying gene expression changes related to auxin and cytokinin pathways.