Y. Wei

This paper identifies the MB0 region of MYC as a direct binder to the PNUTS amino-terminal domain (PAD), revealing a molecular mechanism for MYC regulation by the PNUTS:PP1 phosphatase complex.

This paper assesses the relative risk of underwater released CO2 from ships on marine ecoregions, identifying high-risk areas based on vulnerability and shipping intensity.

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

This study examines how seasonal climate changes in Guangzhou affect Aedes albopictus development and its susceptibility to DENV-2, finding that mosquitoes can still transmit the virus in winter.

The paper uses single-cell transcriptomics to profile viral receptor expression in masked palm civets, identifying potential tissue tropisms for 132 viruses.

This study uses deep metagenomics to explore microbial communities in Challenger Deep sediment, revealing new MAGs, metabolic functions, and virus-host interactions in hadal zone ecosystems.

This study shows that Tmem138 is essential for rhodopsin transport across the photoreceptor connecting cilium and outer segment biogenesis, with its absence causing photoreceptor degeneration.

The paper identifies a novel binding site on α-tubulin and shows that cevipabulin binding to this site induces tubulin degradation.

This study identifies a novel role of low barrier hydrogen bonds in promoting selective tubulin degradation through small molecule interactions.

This study identifies the SCP4-STK35/PDIK1L phosphatase-kinase complex as a critical signaling dependency in AML, showing its role in proliferation and amino acid metabolism through dual regulatory mechanisms.

This study evaluates novel oral tuberculosis regimens containing TB47, clofazimine, and linezolid, showing fast-acting sterilizing activity and no relapse in a mouse model.

This study develops a trimeric RBD vaccine that induces long-term immunity and complete protection against SARS-CoV-2 in nonhuman primates.

This study uses CRISPR/Cas9 to induce homology-independent targeted integration in a rat hemophilia B model, achieving therapeutic correction with 3.66% knock-in efficiency and normalization of clotting time.

This study investigates how nanoparticles exchange between cells, showing that extracellular vesicles significantly facilitate this process.

The paper introduces MRtree, a method to reconstruct cell type hierarchies from scRNA-seq data by reconciling multi-resolution cluster trees, improving upon traditional hierarchical clustering approaches.

This study develops a functionalized ECM scaffold with LXW7-DS-SILY to enhance neovascularization and diabetic wound healing in ZDF rats.

This study develops sPLA2 inhibitor-loaded micellar nanoparticles that reduce inflammation and slow osteoarthritis progression in human and mouse models.

This paper demonstrates that iRGD-liposomes enhance the delivery and efficacy of AR-ASO in treating prostate cancer and bone metastasis without increasing toxicity.

The paper identifies SLC5A3-dependent myo-inositol auxotrophy in AML through genetic screening and shows synthetic lethality between ISYNA1 and SLC5A3.

This paper optimizes microencapsulation of vitamin C in mushroom powder cake to preserve its function during baking and enhance nutritional value.

This study examines how energy substances, reactive oxygen species, enzyme activities, and endogenous hormones influence somatic embryogenesis and abnormal callus formation in Ormosia henryi Prain.

This study identifies a phosphatidylglycerol-dependent, ltaS-independent glycolipid produced by S. pneumoniae, S. mitis, and S. oralis using lipidomic analysis.

This study shows that the bacterial effector RipAC targets PUB4 to inhibit PTI by disrupting BIK1 homeostasis.

This study identifies ALDH2 transcriptional silencing in AML as a dependency on FA proteins, suggesting FA pathway targeting as a therapeutic strategy.

This study shows that the MNK1/2-eIF4E axis promotes immune suppression and metastasis in postpartum breast cancer by affecting both tumor and non-tumor cells.

This study shows that SF3B1 mutations specifically at codon K700E, but not other codons, are independently linked to better overall survival in myelodysplastic syndromes.

This study identifies the optimal N, P, K fertilization model for jujube in the Loess Hilly Region, showing that N1P3K3 maximizes yield and specific quality traits.

This study evaluates the efficacy of the REGN-COV2 antibody cocktail in preventing and treating SARS-CoV-2 infection in rhesus macaques and hamsters, showing reduced virus load and pathological effects.

This study identifies marrow adipogenic lineage precursors (MALPs) as critical regulators of osteoclastogenesis through RANKL expression, showing their role in both normal bone remodeling and pathologic bone loss.

The paper validates a concept using magnetic temporal interference to achieve noninvasive, high-resolution, and localized deep brain stimulation by exploiting low-frequency envelope stimulation from interfering high-frequency fields.