Y. Zhang

This study investigates the distinct roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of factor V and factor VIII, revealing that MCFD2 binds cargo and LMAN1 acts as a shuttling carrier.

This study identifies antibodies effective against Omicron by analyzing epitope changes and binding patterns, showing their ability to neutralize the virus through a conserved mechanism.

This study reevaluates Piezo1's role as a gut RNA sensor and finds that fecal ssRNA does not activate Piezo1, supporting its function in mechanosensation.

This study identifies CURLY LEAF (CLF) as a key regulator of apoplast water status in Arabidopsis by modulating ABA signaling and stomatal closure.

The paper develops a formula to convert GDS-15 scores to GDS-30 scores using a dataset of older adults, finding that multiplying by 2 is inaccurate and providing an alternative formula with higher explained variance.

This study estimates heritability of physiological traits in Porites astreoides across life stages, finding high genetic influence on larval chlorophyll a concentration and variable heritability across traits and stages.

This study determines the structural mechanism of a bacterial ZIP metal transporter, revealing an elevator-type transport mechanism through structural and computational analysis.

The paper shows MATR3 and antisense LINE1 RNAs form a meshwork that organizes chromatin, and their disruption causes chromatin reorganization.

This study shows that ASF1 in Arabidopsis preferentially interacts with the HIRA complex for H3.3-H4 deposition, affecting chromatin structure and gene regulation.

This study shows that far-red light enhances maize's response to herbivore-induced volatiles by altering photosynthesis and phytochrome B signaling.

This study evaluates the in vivo safety and immunoactivity of Jurona virus in hepatocellular carcinoma using proteogenomic analysis, showing tumor regression and enhanced immune responses.

This study shows that loss of ANT1 increases fibrosis and epithelial cell senescence in IPF by causing mitochondrial dysfunction.

The paper investigates the dynamics and function of Munc18-mediated SNARE template complexes using optical tweezers, revealing a dynamic conformational transition that facilitates specific SNAP-25 binding.

The paper characterizes a plastid glycolytic-gluconeogenesis pathway in diatoms, showing its functional roles and environmental regulation.

The paper uses locus-specific proteomics to identify proteins associated with the V region chromatin in SHM and validates their function using a Dot1L inhibitor.

This study identifies βγ-CAT as a fasting-responsive pore-forming protein that facilitates macromolecular nutrient transport via exosome-mediated uptake in starved muscle cells.

The paper predicts MPXV T cell epitopes using VACV epitope data and identifies immunodominant targets to design peptide pools for detecting cross-reactive T cells in vaccinated individuals.

This study identifies FOXA1 and Ku70/Ku80 as direct targets of ivermectin in prostate cancer, showing it induces cell cycle arrest, apoptosis, and synthetic lethality through chromatin accessibility reduction and DNA repair impairment.

This study compares root growth responses of the halophyte Schrenkiella parvula and Arabidopsis thaliana under salt stress, identifying gene regulatory differences and physiological adaptations that enable salt tolerance.

This paper identifies an antibody, WS6, from a mouse immunized with SARS-CoV-2 spike mRNA, which neutralizes diverse beta-coronaviruses by targeting a conserved helical epitope on the S2 subunit.

The paper shows that SMNDC1, an upregulated splicing factor in cancer, promotes tumor growth by enhancing ERK1 kinase activity through altered RNA splicing of exon 4.

This study identifies Chlamydia trachomatis proteins that target mitochondria and alter their protein composition during infection, affecting apoptosis and metabolism.

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

This study shows cAMP competitively inhibits periplasmic phosphatases in H. influenzae, linking nucleotide utilization to competence development.

This study investigates the role of human LAMP1 in LASV fusion, showing it accelerates pore formation but only modestly increases infection, with enhanced pore dilation when fusion is forced at the plasma membrane.

This paper identifies a 4-bp deletion in the maize ZmSOS1 gene that causes salt sensitivity and develops a molecular marker to improve salt tolerance in breeding programs.

The paper develops a computational pipeline combining Rosetta and cryo-EM to analyze ACE2 receptor traps' binding to SARS-CoV-2 variants, showing high affinity and neutralization capabilities against Omicron and Delta.

This paper introduces PRIME-PAINT, a method for multiplexed fluorescence nanoscopy with millimeter-scale field-of-view and high resolution, demonstrating its use on biological samples.

This study shows that the p73{gamma}-Leptin pathway promotes tumorigenesis and alters lipid metabolism by demonstrating that E11 deletion increases p73{gamma} and Leptin, leading to oncogenic effects in mice and human cancers.