Y. Zhang

This paper develops a PLS model combining retrosynthesis-based molecular representations and MD simulations to predict koff values for HSP90 inhibitors, showing high correlation with experimental data.

This study investigates children's preference for using prototypes over analytical methods in scientific concept learning, finding a strong preference for prototype matching.

This paper introduces a soft, stretchable organic bioelectronic system for continuous intra-operative neurophysiological monitoring during microsurgery, demonstrating improved signal quality and reduced post-operative complications in animal models.

This study uses association rule mining to analyze the human gut microbiome, identifying higher-order microbial relationships and showing improved disease classification.

This study optimizes protein extraction methods for human sperm and investigates antibiotic effects on sperm proteome, finding increased concentration and malformed sperm with altered proteome expression.

The paper identifies two Keap1 isoforms that interact with Smad2/3, enhancing their stability and transcriptional activity, and reveals a novel crosstalk between the Keap1-Nrf2 and TGF-β1-Smad2/3 pathways.

This paper develops mRNA vaccines against Monkeypox virus that protect mice from lethal infection, with fusion protein vaccines showing better immune responses than separate protein vaccines.

This paper introduces a 3D spheroid-microvasculature-on-a-chip model to study tumor-endothelium mechanobiology interactions under controlled flow conditions.

This study shows that scavenging reactive dicarbonyls with PPM reduces atherosclerosis and insulin resistance in Ldlr-/- mice by improving HDL function and reducing inflammation.

This study compares the neutralizing antibody responses induced by monovalent and bivalent BA.4/5 vaccines against multiple Omicron sublineages in individuals over 55 years old, finding the bivalent vaccine elicits stronger neutralization.

This paper demonstrates that planarians can navigate to a previously recognized location in a new maze, indicating they have spatial localization ability.

This paper proposes a deep learning-based sound coding strategy for cochlear implants that improves speech intelligibility in noisy environments.

The paper shows that schooling fish reduce energy use per tail beat by up to 56% at high speeds compared to solitary fish, with significant aerobic and anaerobic benefits.

This study shows that intratumoral MMR vaccine injections inhibit tumor growth and improve survival in mouse cancer models by enhancing cytotoxic T-cell responses.

This study identifies ORF8 as a SARS-CoV-2 protein that reduces Spike antigen levels on infected cells, thereby limiting antibody recognition and immune evasion.

The paper shows that DNA virus components are packaged into exosomes by infected crustacean cells, which transmit apoptotic signals to suppress viral spread.

The paper identifies RNA phase separation as a novel pathway for extracellular miRNA uptake and shows that these miRNAs are delivered to mitochondria via PNPT1.

This study shows that oral nanoplastic exposure in mice leads to gut macrophage activation and IL-1β production, which affects brain function by causing microglial activation and cognitive decline.

This study evaluates UAV-based remote sensing for predicting nitrogen content and nitrogen agronomic efficiency in winter wheat organs using vegetation indices and texture features.

This paper introduces DeepSeMi, a self-supervised denoising framework that enhances fluorescence microscopy by increasing SNR and enabling long-term, high-resolution imaging of cellular processes.

The paper introduces deep-APQ, a proteome quantitation method using segmented MS/MS acquisition of a1 ions, showing improved coverage and accuracy in E. coli proteome analysis.

This study shows P body factors coat germ granules in C. elegans to enable transgenerational gene silencing by maintaining small RNA factors and secondary small RNA amplification.

The paper demonstrates the existence of protein complexes in the dilute phase of phase-separating systems using an algal pyrenoid reconstitution system and fluorescence correlation spectroscopy.

This study isolates melanoma cells based on melanin content, finding that low-pigment cells are more abundant and have higher tumorigenic potential than high-pigment cells.

This study develops 3D-printed cerebral cortical tissues with layer-specific organization and integration into mouse brain explants, showing neuronal connectivity and potential for personalized medicine.

The paper identifies an alternative pathway for malonyl-CoA production using oxaloacetate dehydrogenase in Streptomyces, enabling efficient bioproduction of malonyl-CoA-derived chemicals in E. coli.

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

This study identifies PhoP as a key regulator of pathogenicity in Riemerella anatipestifer by combining DAP-seq and transcriptome analysis, showing its role in aerotolerance and virulence.

This study investigates CXCL4 signaling in human monocytes, identifying NF-κB and TBK1-JNK pathways and a potential role for TLR4, while noting challenges in isolating CXCL4's effects from endotoxin contamination.