Y. Zhang

This study investigates how CAMSAP proteins and CDK5RAP2 regulate microtubule release from γ-TuRC, revealing their roles in microtubule nucleation and stabilization.

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

This study identifies TMEM65's role in mitochondrial calcium regulation, showing its loss causes mitochondrial disease and suggesting therapeutic targeting of mitochondrial calcium as a potential treatment.

The paper demonstrates that swim bladder resonance enhances hearing in crucian carp through auditory evoked potentials, Micro-CT, and numerical simulations.

The paper reports cryo-EM structures of FSHR in inactive and active states, revealing a conserved activation mechanism and the role of H6157.42 in agonist selectivity.

The paper uses electric fields to induce migration in human keratinocyte sheets and develops an in silico model showing how directional cues propagate to drive coherent collective migration.

This paper develops multispecific antibodies that neutralize all SARS-CoV-2 variants, including Omicron, by targeting multiple epitopes on the spike protein.

This study shows porcine STING has antiviral activity independent of IFN and autophagy, and also triggers apoptosis to resist viral infections.

This study investigates how Oreorchis patens responds to cold stress by analyzing physiological, biochemical, and molecular mechanisms, identifying differentially expressed genes and confirming their roles through qRT-PCR.

This paper reports a high-affinity antibody that binds to a glycopeptide with consecutive glycosylation sites, showing that glycan modification near the epitope significantly increases antigenicity.

The paper identifies allele-specific functional differences among EGFR exon 19 deletion variants, showing how sequence and structure motifs affect oncogenic activity, dimerization, and TKI sensitivity.

This study investigates Cu-dependent antioxidant defenses in mitochondria and cytosol using redox sensors and proteomics, revealing distinct redox responses and protein changes in each compartment.

This paper describes a method to generate human atrial-like cardiomyocytes from induced pluripotent stem cells that respond to adrenoceptor agonists.

This study examines two anoxic foraminifera, revealing distinct mitochondrial and peroxisomal metabolic strategies that support their survival in low-oxygen environments.

This study identifies βγ-CAT as a pore-forming protein that enables cells to scavenge extracellular proteins under starvation by promoting nutrient uptake and survival.

This paper shows that recombination is suppressed around the mating-type locus in Schizothecium tetrasporum, a fungus in the Sordariales order, leading to self-fertile dikaryotic spores through stepwise recombination suppression.

This study identifies H2BFWT's role in spermatogenesis by showing its impact on nucleosome stability and gene expression through structural and functional analyses.

This study analyzes fecal metagenomes to identify viral signatures associated with colorectal cancer and adenoma, finding distinct virome patterns and developing predictive models with high accuracy.

This study identifies how melanoma cells use pericyte:endothelial cell signaling during brain invasion, showing that Sox9hi mesenchymal cells use Snail1-dependent mechanisms while Sox10hi cells form clusters.

This study investigates how two Keap1 isoforms, α and β, differentially inhibit Nrf2 and influence malignant behaviors in hepatocellular carcinoma.

This study reports cryo-EM structures of Omicron subvariant S proteins, revealing conformational differences linked to transmissibility and immune evasion.

This study uses a modified Lattice Light Sheet Microscope to analyze Legionella pneumophila infection dynamics and morphology.

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

This paper identifies BysR as a LysR-type regulator that activates ambR1 to control occidiofungin production in Burkholderia sp. JP2-270 and reveals its broader regulatory role in metabolism and motility.

This paper determines the structure of an anellovirus, revealing how its unique surface features enable immune evasion by hiding conserved epitopes and exposing diverse ones as decoys.

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.

This study shows that overexpressing mitochondrial-targeted glutamine synthetase in tomato leaves increases assimilate export, leading to earlier flowering and higher yield.

This paper introduces MIP-FLF microscopy to enable fast, volumetric infrared spectroscopic imaging of living cells and organisms, revealing lipid metabolism changes in drug-resistant pancreatic cancer cells.

This paper investigates the distinct roles of Nrf1 and Nrf2 in the reductive stress response to DTT, showing differential regulation of redox and ER stress defense genes.

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.