Y. Zhang

The paper identifies a genetic locus associated with root bending in response to salinity, showing that extensin arabinosylation is required for directional root responses to salt.

The paper validates on-target and off-target effects of anti-Cryptosporidium drugs using a novel MDR1-transgenic host cell model and algorithms to quantify drug action contributions.

The paper examines how changes in generation time affect human mutation spectra, finding that such changes cannot fully explain observed mutation patterns, suggesting other factors are involved.

This paper introduces a new eccDNA purification method and a full-length sequencing approach to improve eccDNA analysis and mapping.

The paper constructs a promoter-GFP fusion reporter library to study the systemic expression patterns of 41 c-di-GMP metabolism-related genes in Pseudomonas aeruginosa under various growth conditions.

The paper identifies lineage-specific genes (LSGs) in Neurospora crassa that cluster with allorecognition loci and respond to environmental factors regulating the switch from asexual to sexual reproduction.

This study shows HDAC3 is essential for pDC development and hematopoietic progenitor homeostasis, with HDAC3 repressing cDC1-associated genes to promote pDC differentiation.

This study introduces a metallo-supramolecular branched polymer to improve particle distribution in single-particle cryo-EM by preventing air-water interface damage and preferred orientation.

The paper shows that shade-induced transcription of PIF-Direct-Target Genes occurs before H3K4me3 chromatin modification increases, suggesting H3K4me3 may buffer rather than cause shade-induced gene expression.

The paper develops adenine base editors in Arabidopsis thaliana that can induce inheritable A-to-G mutations in non-canonical PAM contexts with high efficiency.

This study demonstrates survival intravascular photoacoustic imaging of lipid-rich atherosclerotic plaques in a rabbit model using MRI-guided IVPA catheter, validated by histology.

The paper isolates rare memory B cells from vaccinated individuals to generate anti-poxvirus monoclonal antibodies, identifying one with high efficacy against viral infection.

The paper identifies novel NHP metabolites in Arabidopsis and shows that their methyl ester form can rescue a biosynthesis mutant's disease susceptibility.

This paper shows that a chitosan oligosaccharide analog disrupts fungal cell wall organization by targeting PHR transglucosidases, leading to antifungal activity and synergy with existing fungicides.

The paper identifies mesothelial cell-derived antigen-presenting CAFs in pancreatic cancer that induce regulatory T cells through antigen-specific interactions.

The paper identifies nalacin as an inhibitor of GH3 amido synthetase, which regulates auxin conjugation in plants, with potential applications in agriculture and research.

The paper develops a red-shifted NanoLuc variant (QLuc) and uses it for in vivo immunobioluminescence imaging to improve deep-tissue visualization in mice.

This study shows that SARS-CoV-1 survivors vaccinated with ZF2001 have reduced neutralization against SARS-CoV-2 Omicron compared to other variants.

This study identifies Pcr2 as a critical protein for movement and invasion in Toxoplasma gondii, showing that its absence impairs egress and tissue destruction.

This study identifies self-organized canals in bacterial colonies that enable long-range directed transport of cells and vesicles, driven by biosurfactant-mediated fluid flows.

This study uses single-cell RNA sequencing to analyze shrimp hemocytes, revealing evolutionary parallels between invertebrate and vertebrate myeloid cells.

This study uses a single contrast agent to simultaneously image multiple anatomical structures in live mice via photoacoustic microscopy for up to 3 hours.

The paper develops a gradient-based optimization method to recover ionic current conductances from action potentials of hiPSC-CMs, showing convergence to the original parameter values.

This study shows that reducing CTPS in the fat body of Drosophila alleviates HFD-induced obesity by decreasing lipid storage and TAG levels.

This study identifies a necroptosis-related gene signature (NRGscore) to predict prognosis and therapeutic response in bladder cancer patients using TCGA data.

This study identifies three molecular subtypes of synovial sarcoma through multi-omics analysis, linking BAF complex alterations to tumor evolution and clinical outcomes.

This study shows Hsp27 binds phosphorylated Tau to prevent its aggregation and mitigate AD pathology.

This study shows SHH signaling stabilizes primary cilium length through crosstalk with EP4 prostaglandin signaling, ensuring proper SHH pathway function.

The paper analyzes single-cell RNAseq data from metastatic castration-sensitive prostate cancer patients treated with anti-PD-1 immunotherapy, showing increased immune infiltrate and identifying therapy-resistant tumor subpopulations and druggable targets.

This study analyzes the temporal transcriptome changes in porcine macrophages infected with different ASFV strains to understand viral pathogenicity and host response dynamics.