B. Zhang

The paper uses single-cell RNA analysis to compare immune cell profiles in young and old mice, finding higher proportions of effector cells in old mice that may enhance tumor defense.

The paper develops a deep-learning method to segment and analyze cardiac mechanics in developing zebrafish, revealing incremental volume changes in ventricles and stable stroke volume in atria.

This paper shows that copper signaling modulates protein turnover by allosterically activating ubiquitin E2D conjugases, linking copper levels to protein degradation and morphogenesis.

This study evaluates the neutralization resistance of SARS-CoV-2 variants B.1.1.7 and B.1.351 to monoclonal antibodies and sera, finding increased resistance in B.1.351.

This study identifies PDGFRβ as a host factor required for JEV infection and shows that imatinib can protect against JEV by reducing viral load and histopathology.

This study shows that adipocyte lipolysis, regulated by Wnt signaling and DPP4, reduces skin fibrosis by modulating ECM homeostasis.

This study identifies a mixture of polysaccharides from Ecklonia kurome that inhibit SARS-CoV-2 by targeting multiple viral proteins, with the cocktail-like effect enhancing antiviral activity.

The paper determines structures of three VH1-2-derived antibodies in complex with SARS-CoV-2 spike, revealing modular recognition mechanisms and conformational changes.

This study investigates the stability and folding pathways of a tetra-nucleosome using a near-atomistic model and deep learning, revealing the zigzag structure as a global minimum but not the dominant configuration.

This paper introduces a force field, MOFF, that accurately models both ordered and disordered proteins and applies it to study HP1 homologs' phase separation behavior.

The paper identifies Cop1 as a modulator of macrophage infiltration and cancer immunotherapy in TNBC by using in vivo CRISPR screens and multi-omics analyses.

The paper evaluates a PKC inhibitor in a T2D rat model, finding it halts renal decline indirectly via reduced hyperphagia and directly lowers adiposity.

This paper introduces a Bayesian changepoint Gaussian Processes model to automatically fit PROTAC concentration-response curves, enabling accurate parameter estimation and compound ranking without manual intervention.

This paper reports a monoclonal antibody, 3E8, that blocks multiple coronaviruses by targeting ACE2, showing broad-spectrum activity against SARS-CoV-2 variants and other coronaviruses.

The paper identifies a CD127-expressing monocyte subset, M127, associated with anti-inflammatory properties in inflammatory diseases and correlates its expansion with milder COVID-19 outcomes.

This study uses pH-sensitive fluorescent protein to track vacuolar pH changes during cell-in-cell mediated death, revealing distinct pH dynamics in entotic and apoptotic death and their implications for cancer treatment.

This study identifies aglycone polyether ionophores as broad-spectrum antivirals effective against multiple enveloped viruses, including SARS-CoV-2, and demonstrates their efficacy in curing JEV-infected mice.

The paper introduces Deep-LUMEN, a deep learning algorithm for classifying lung epithelial spheroids from brightfield images, and validates its ability to detect morphological changes in response to drug treatments.

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

This study uses smFRET to observe real-time conformational dynamics of SARS-CoV-2 spikes on virus particles, revealing multiple states and mechanisms of neutralization by antibodies and convalescent plasma.

This study shows EPAC1 regulates vWF secretion from endothelial cells during inflammation via the PI3K/eNOS pathway, with implications for thrombosis control.

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

This paper uses cryo-EM to show how SARS-CoV-2 spike protein undergoes pH-dependent structural changes that affect ACE2 binding and antibody evasion.

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

The paper develops biotin-labeled SARS-CoV-2 spike molecular probes using structure-based design and purification methods, achieving high yields and enabling antibody characterization.

The paper examines age-dependent glycomic responses to the 2009 H1N1 influenza virus and links these responses to disease severity in a ferret model.

This study evaluates how bead-beating intensity affects DNA extraction from mouse and human stool, finding that 4 minutes of beating optimizes microbiome recovery for most taxa.

The paper develops a mathematical framework to analyze epigenetic stability using stochastic reaction networks and applies it to a chromatin state model to identify bistability and transition paths.

This paper develops a nanoparticle platform for displaying trimeric antigens, showing that SARS-CoV-2 spike-LuS nanoparticles induce 25-fold higher neutralizing responses than spike alone.

This study evaluates the therapeutic effects of IL12IL2GMCSF fusion protein in canine tumors, showing significant response rates with minimal adverse effects.