D. Wang

This study shows that Myostatin gene deletion in pigs alters gut microbiota, increasing SCFAs which stimulate fast-twitch glycolytic muscle growth through the Akt/mTOR pathway.

This study shows DHODH inhibition enhances immune checkpoint blockade by increasing cancer cell antigen presentation through pyrimidine depletion and P-TEFb-mediated RNA polymerase II elongation.

The paper investigates the role of Acinetobacter in EBPR systems using 16S sequencing and SCRS-FISH, finding Acinetobacter dominance and its contribution to phosphorus removal under specific operational conditions.

This study shows that p38α inhibition reduces immunosuppression by MDSCs and enhances immunotherapy in TNBC by decreasing CXCL1/CXCL2 expression.

The paper shows that sulfonamides induce hormesis in Comamonas testosteroni by activating a quorum-sensing gene that enhances nucleotide synthesis for cell proliferation.

The paper demonstrates an integrated wastewater treatment process that achieves nitrite accumulation through comammox and unknown AOBs, revealing their role in short-cut nitrogen removal.

This study identifies BNC1-PRMT1 as a transcriptional axis promoting SCC growth, showing PRMT1 inhibition reduces tumor size without affecting migration.

The paper shows that urolithin A enhances AHR activity in gut and lung tissues by reducing clearance via CYP1A1/1B1, suggesting a role for dietary substrates in modulating AHR signaling through the gut-lung axis.

The paper identifies a new AOA order, Nitrosomirales, widespread in marine and terrestrial environments, showing metabolic versatility and horizontal gene transfer.

The paper shows that PTEFb enables rapid transcriptional reorganization in glioma cells after radiotherapy, enhancing survival, and that inhibiting PTEFb reduces this response and increases cell death.

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

The paper investigates how dalpiciclib affects ER signaling activation induced by pyrotinib in HER2+HR+ breast cancer and identifies CALML5 as a risk factor.

This study shows FAM76B inhibits NF-κB-mediated inflammation by affecting hnRNPA2B1 translocation in vitro and in a TBI mouse model, and identifies its interaction with hnRNPA2B1 in human TBI and neurodegenerative disease tissues.

This study develops a sensitive top-down proteomics method to analyze large proteoforms in single muscle cells, revealing heterogeneity and linking it to muscle fiber types.

This study maps the phylogenetic distribution and ecological lifestyles of root-associated fungi in orchids using a comprehensive DNA dataset, revealing high fungal diversity in orchid mycorrhizal symbiosis.

The paper models how RecA in E. coli balances genomic stability and evolution by testing homology with increasing stringency, predicting that 50 bp of testing is needed for accurate allelic pairing.

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

This study identifies regulators of wheat spike development through multi-omic analysis and GWAS, revealing novel transcription factors that influence spike architecture and flowering time.

This paper proposes a deep learning model for multi-label bacterial classification, showing it is lighter, faster, more accurate, and efficient than existing methods.

This study evaluates the combined developmental toxicity of cyhalofop-butyl and quizalofop-p-ethyl on zebrafish embryos, finding an antagonistic effect and altered gene expression related to apoptosis and cardiac development.

This paper develops a host-guest chemistry strategy using cyclodextrins to stabilize GSNO and control NO release, improving its therapeutic and anti-infective applications.

This study identifies a population of oxytocinergic sympathetic neurons that regulate adipose tissue lipolysis and metabolic homeostasis in mice and humans.

This study develops a culture model to expand adult tubular microvessels on stiff substrates using endothelial cells and pericytes from the same tissue, showing improved growth and morphology with a custom medium.

The paper identifies a subset of bone marrow endothelial cells in adult mice that generate hematopoietic progenitors and mature blood cells through endothelial-to-hematopoietic transition.

This study examines how socioeconomic status across the life course affects BMI trajectories and obesity risk in China using longitudinal data from the China Health and Nutrition Survey.

This study shows that synthetic sensor NLR receptors require multiple interfaces within and outside their integrated domain to recognize noncorresponding effectors and activate resistance.

This study identifies endothelial mitophagy as a source of mitochondrial formyl proteins that activate neutrophils and contribute to lung inflammation.