F. Zhang

This study identifies PcDHCR7 in Phytophthora capsici as a {bigtriangleup}7-sterol reductase essential for mycelium development and pathogenicity.

This study identifies IDH2 as a targetable regulator of drug resistance in CML by analyzing proteomic changes in resistant K562 cells.

This study shows that androgen receptor (AR) and its co-activator MED1 form dynamic, AR-rich condensates at superenhancers in prostate cancer, which are crucial for oncogenic gene expression.

This study identifies natural genetic variation in C. elegans that drives microbiome assembly by influencing immune, xenobiotic, and metabolic signaling pathways.

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

The paper assembles a chromosome-scale, allele-aware autotetraploid genome of alfalfa cultivar Zhongmu-4 and identifies 101 SNPs associated with 27 agronomic traits using GWAS.

This paper develops a mucosal RSV vaccine, P-KFD1, which protects mice against RSV infection without vaccine-enhanced disease and relies on CD4+ T cell responses mediated by IFN-γ or IL-17A.

This paper develops tandem-cleavage linkers to improve ADC stability and tolerability, showing better hematopoietic safety in rat studies.

This study identifies ERK1/2-mediated phosphorylation of NRF1 as critical for proteasome production and stress resistance, showing therapeutic potential in cancer.

This study designs non-covalent SARS-CoV-2 Mpro inhibitors using structure-based design and Ugi-4CR reactions, identifying 23R as the most potent compound with antiviral activity.

This study analyzes 300,000 SARS-CoV-2 genomes to show ongoing adaptive evolution, with positive selection in spike and nucleocapsid proteins and regional diversification over time.

This study compares the temporal transcriptomes of two Verticillium dahliae strains to identify pectin degradation genes linked to pathogenicity in Upland cotton.

This study investigates how platelet-activating factor (PAF) affects the barrier function of ARPE-19 cells by altering tight junctions and VEGF expression.

The paper shows SMIFH2 inhibits myosin ATPase activity and actin filament translocation, affecting myosin 2A, myosin 10, and other non-muscle myosins, suggesting caution in using SMIFH2 to infer formin function.

This study shows TRPC5 inhibition protects human podocytes from injury in vitro and in vivo, supporting its therapeutic potential for kidney diseases.

Ilomastat improves mouse survival after irradiation by enhancing hematopoietic recovery through reduced inflammation and increased stem cell counts.

This study examines how maize plants respond to drought, flooding, and rewatering, finding that photosynthetic traits recover after rewatering, with resilience depending on drought severity and plant growth stage.

This study shows that CHMP5 regulates bone formation by controlling endolysosome-mitochondrion-mediated cell senescence, and targeting senescent cells can alleviate musculoskeletal abnormalities.

The paper shows SARS-CoV-2 variants resistant to neutralizing antibodies can be selected and are present in circulating populations, suggesting the need for combination antibody therapies.

B cells integrate innate TLR and adaptive CD40 signals to induce BATF3 transcription factor for production of IL-27, which together with INFg optimizes antibody responses.

This study evaluates the antiviral activity of heparin and enoxaparin derivatives against SARS-CoV-2 by testing their ability to neutralize pseudotyped virus particles.

The paper introduces oxView and open-source tools for visualizing and analyzing large DNA/RNA nanostructures simulated with oxDNA, enabling design, optimization, and structural analysis.

This paper develops and evaluates [68Ga]Ga-NOTA-folate (68Ga-FOL) as a PET tracer for imaging FR-{beta}-positive macrophages in atherosclerosis, showing high affinity and specificity.

The paper reports the crystal structure of the STENOFOLIA homeodomain bound to DNA, revealing a novel tetrameric binding mechanism and its role in transcriptional repression.

This paper identifies N-glycosylation as essential for Phytophthora sojae growth and pathogenicity, revealing two distinct N-glycosylation motifs and their functional roles in key life stages.

The paper introduces CeMbio, a simplified natural microbiota for C. elegans, enabling causal studies of host-microbiome interactions through a resource with culturable strains and associated tools.

This meta-analysis compares oncologic outcomes of T1 glottic carcinoma treated with transoral laser surgery or linear accelerator radiotherapy, finding better overall survival and laryngeal preservation with surgery.

This study identifies a glycosaminoglycan-binding motif in SARS-CoV-2 spike glycoprotein that enhances binding to heparin, suggesting a role in host cell entry and potential for carbohydrate-based therapies.

This paper develops a multiplexed CRISPR/Cas9 system with Trex2 exonuclease to improve genome editing efficiency in Setaria viridis, achieving high mutation rates and MMEJ-mediated repair.

The paper shows that inhibiting nonsense-mediated decay increases expression of p53β/γ isoforms, which are resistant to MDM2 degradation, thereby restoring p53 function in cancers with MDM2 amplification, HPV infection, or specific p53 mutations.