J. Chen

This paper develops a heart-on-a-chip model to study immune-induced cardiac dysfunction, identifying mitochondrial DNA as a key factor and showing therapeutic potential of endothelial exosomes.

This study shows that mtDNA released by senescent cells triggers immunosuppression via PMN-MDSCs, and inhibiting this pathway enhances therapy-induced senescence in cancer.

This study identifies FAM210A as a mediator of mitochondrial-ribosome crosstalk that supports protein synthesis and muscle growth in mice.

The paper shows TIR domains interact with EDS1 family proteins and helper NLRs to propagate immune signaling in plants.

The paper constructs gene catalogs and metagenome-assembled genomes from the swine lower respiratory tract microbiome and identifies associations between microbial species and lung lesions.

This study identifies miPEP156e, a miRNA-encoded peptide in rice, which enhances cadmium tolerance by modulating ROS and Cd transporter genes.

This study shows cold temperature activates human platelets via TRPM8-dependent and -independent mechanisms, with TRPM8 involved in early activation and ER calcium release driving later responses.

This study quantifies glutathione dynamics in living cells using a reversible fluorescent probe, demonstrating its sensitivity and applicability in high-throughput imaging.

This study identifies conserved myeloid subsets and disease-associated gene expression changes in kidney injury across lupus mouse models and human patients with lupus nephritis.

This study identifies CtUGT3 as the key UGT enzyme responsible for astragalin biosynthesis in safflower through metabolomics, transcriptome analysis, and biochemical experiments.

The paper determines TAP structures with peptides to show how it selects peptides by length while allowing sequence diversity through terminal interactions.

This study shows that mechanically stimulated osteocytes release extracellular vesicles containing microRNAs that inhibit NSCLC cell proliferation and bone metastasis progression.

This study shows that the agr quorum-sensing system in Staphylococcus aureus primes the bacteria to resist oxidative stress by controlling reactive oxygen species, even when the system is not actively activated.

AGILE uses deep learning and combinatorial chemistry to rapidly design and evaluate ionizable lipids for mRNA delivery, revealing cell-specific preferences for lipid structures.

This study identifies tumor-specific neutrophils in glioblastoma that originate from meninges and contribute to immunosuppression, showing their role in tumor progression and poor prognosis.

This study characterizes the first complete mitochondrial genome of Sphaeniscus atilius and presents phylogenetic insights for Tephritidae family relationships.

This study shows that STING is required for TLR8-induced IFN production in human monocytes and reveals a new crosstalk mechanism between cytosolic and endosomal innate immune receptors.

This study identifies and characterizes two covalent PLpro inhibitors, HUP0109 and DX-027, as potential treatments for SARS-CoV-2.

This study investigates the formation of the sporoplasm membrane during microsporidia spore germination, revealing that the polaroplast transforms into the sporoplasm membrane via the polar tube.

This paper develops a pooled effector library screening platform in plant protoplasts to identify Avr genes interacting with R genes, validating it by discovering known and novel Avr genes from wheat stem rust.

This study introduces NOBEL-SPA to analyze EV sub-populations by colocalizing protein and miRNA markers, identifying unique signatures for early breast cancer detection.

This study shows that serum from pregnant donors can stimulate human beta cell proliferation and insulin secretion, suggesting potential for beta cell expansion.

This study examines Listeria species in beach sand, identifying hypervirulent isolates and their potential role in human listeriosis.

The paper shows that micropolarity differences between subcompartments dictate the structural organization of biomolecular condensates, leading to layered structures and functional changes.

The paper examines how experimental heatwaves and warming affect community responses in a multi-trophic system, showing distinct impacts based on climate type and species interactions.

The paper shows that SNC1, an immune receptor, guards ADR1-L1 and ADR1-L2 from bacterial effector suppression, enabling plant immunity through sequence diversification and a layered defense system.

This study shows HCC-1 promotes atherosclerosis by inducing pyroptosis in endothelial cells and macrophages and suggests it as an early diagnostic biomarker.

This paper introduces a hierarchical strategy using CXMS and AlphaFold2 to analyze protein dynamics in vivo, focusing on IDPs and multi-domain proteins.

This study identifies CD25 as a scaffold for phosphatases that regulate B-cell signaling and oncogenic processes, with opposing effects on B-cell malignancies and autoimmunity.

This study identifies a unique vulnerability in B-cell malignancies where GSK3β inhibitors disrupt β-catenin-Ikaros complexes, leading to MYC repression and cell death.