J. He

This study shows ECM-detached cancer cells resist ferroptosis due to reduced free iron levels from altered iron metabolism, suggesting potential limitations for ferroptosis-based therapies.

The paper investigates plant microbiome assembly in mulberry, finding that host selection and microbial size influence biogeographic patterns and community dynamics.

This study shows that exercise training remodels iWAT ECM, increases vascularization and innervation, and alters adipocyte subpopulations in male mice.

This paper establishes Physalis as a new Solanaceae model system by presenting chromosome-scale genomes and identifying genetic factors influencing floral traits and the Inflated Calyx Syndrome.

The paper identifies ID1 as an autonomous phosphate regulator that modulates the miR399-ZmPHO2 signaling module to maintain Pi homeostasis in maize.

This study engineers a SARS-CoV-2 spike protein with a disulfide bond to stabilize the locked conformation, revealing structural dynamics and the role of domain D in conformational changes and viral fitness.

This paper shows that Vitamin C reduces ACE2 protein levels and blocks SARS-CoV-2 infection in cell and mouse models by inhibiting USP50-ACE2 interaction.

This paper integrates single-cell RNA sequencing data with organoid co-cultures to study inflammatory signaling in pancreatic cancer and validates findings through transfer learning and mechanistic experiments.

This study identifies TUT1-regulated alternative splicing of NCOR2 producing NCOR2-013 as a mechanism by which Talaromyces marneffei suppresses macrophage inflammation.

The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.

The paper identifies miRNA targets in maize using PARE datasets, revealing tissue-specific cleavage and new miRNA-target pairs involved in seed germination.

This study analyzes the spatiotemporal patterns of scrub typhus in China from 2012 to 2018, identifying key meteorological, environmental, and socio-economic factors influencing its distribution.

This study shows cardiac patches reduce ischemic cardiomyopathy by lowering mechanical load and reverting Piezo1/2 expression in the left ventricle.

This study uses hit-and-run silencing to suppress DUX4 in FSHD patient-derived iPSCs by targeting DNA hypomethylation on D4Z4 repeats, achieving sustained suppression for at least two weeks.

This study identifies the role of renal macrophages in clearing intratubular particles and preventing kidney stone formation through phagocytosis and transmigration.

This paper introduces DeepCAD-RT, a real-time denoising method for fluorescence time-lapse imaging that improves signal-to-noise ratio with fewer photons, demonstrated across multiple organisms and biological processes.

The paper identifies Ect2 and RGA-3/4 as core components of a cortical excitability circuit and demonstrates the immature Xenopus oocyte as a model for studying excitable dynamics.

This paper introduces Spinning Disk Multifocal Microscopy (SDiM) for high-speed, high-resolution imaging of large biological surfaces, demonstrating its application in cortical and immune cell studies.

This study analyzes the impact of socio-economic factors on surface water quality at provincial boundaries in China, identifying key factors affecting water quality.

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

This study shows that humanized mice can be infected by SARS-CoV-2, leading to immune responses and immunopathology, providing a model for studying the virus and testing therapies.

The paper identifies a wound-like tumor periphery in breast cancer as a uniparameter marker predicting multidrug nonresponse and poor prognosis across molecular subtypes.

This study identifies quantitative trait loci (QTLs) associated with vegetative phase change in Arabidopsis thaliana accessions, revealing distinct genetic mechanisms for different developmental transitions.

The paper isolates and characterizes two novel photosystem I supercomplexes from cyanobacteria, revealing the structure of the PSI octamer at near-atomic resolution.

This study shows drought reduces sucrose transport from cottonseed coat to fiber and disrupts sucrose allocation, leading to decreased cellulose synthesis and fiber strength.

The paper identifies ERN1, a G-lectin receptor kinase, as a negative regulator of Arabidopsis immunity against root-knot nematodes by suppressing defense responses.

The paper uses spatial transcriptomics to identify antiparasitic targets in Brugia malayi head tissues, revealing new drug and vaccine candidates.

This study examines how cannabinoids affect ethanol-related behaviors and developmental outcomes in Drosophila, finding differential effects on tolerance and developmental defects.

This study shows ASH1L's enzymatic activity is essential for MLL-AF9-induced leukemogenesis by enhancing target gene expression through histone modification.