J. He

This study shows that STAT3 deficiency in dendritic cells leads to colitis in mice, which is dependent on the gut microbiome.

This study uses silica-dried leaf tissues for RNA-seq and phylotranscriptomic analysis, showing they are viable for phylogenomic studies with results comparable to liquid nitrogen-preserved samples.

A toolset for simultaneous imaging of Ca2+ dynamics in subcellular compartments has uncovered unrecognized Ca2+ signatures in Arabidopsis cells in response to developmental and external cues.

This study profiles the tumor immune microenvironment of NSCLC using multiplex immunofluorescence, identifying three immune subtypes and an immune-related risk score for prognosis prediction.

This study examines how nitrification inhibitors and straw incorporation affect N2O emissions and microbial communities in different cropland soils, finding that their effects vary by soil type.

This study identifies endophilin A1 as a calmodulin effector that drives dendritic spine enlargement via actin polymerization during LTP induction.

This study identifies a p53-like transcription activation domain in PIF3 and shows that PHYB binding inhibits its activity, revealing a photoresponsive transcriptional switch in Arabidopsis.

The paper shows that Clp protease and AscarD regulate CarD levels to help mycobacteria survive starvation by reducing rRNA synthesis.

This paper uses Maxent modeling to predict the global distribution of talaromycosis, identifying key environmental and epidemiological drivers.

The paper develops a miniaturized aerosol sampling device inspired by wet scrubbers, demonstrating efficient aerosol capture and viability retention of bioaerosols.

Analysis of multiple tmk mutants reveals key roles of TMKs in plant development, including organogenesis, leaf size, fertility, and selfing population defects.

This study shows VAL genes regulate vegetative phase change through both miR156-dependent and independent mechanisms in plants.

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

This study shows cannabinoids affect food preference and consumption in Drosophila without requiring cannabinoid receptors, with some inhibiting intake and others promoting starvation resistance.

This study identifies immune markers, including HLA-DR and CTLA-4 expression on CD4 T cells, that predict HBsAg loss in chronic hepatitis B patients.

This study investigates the role of YAP1 in TNF-α-induced proliferation and osteogenic differentiation of human periodontal ligament stem cells, finding that YAP1 enhances cell proliferation and differentiation via the Hippo signaling pathway.

The paper identifies ERG's role in prostate cancer by showing it inhibits basal cell differentiation through chromatin interactions, promoting luminal cell fate.

The paper develops scAAVengr, a single-cell pipeline to quantify AAV gene expression efficiency in non-human primate retina, demonstrating its utility with a top-performing AAV variant.

BacAnt is a webserver that simultaneously annotates antibiotic resistance genes, integrons, and transposable elements in bacterial DNA sequences, generating automated genbank files.

This study shows that human lung organoids can model SARS-CoV-2 infection and drug response, revealing virus targets and effective antiviral treatment.

This study shows SARS-CoV-2 suppresses selenoprotein mRNA expression linked to ferroptosis, ER stress, and DNA synthesis, while increasing IL-6 expression in Vero cells.

This study conducts a meta-analysis of 12 articles to evaluate the protective effect of FMDV VP1 protein on animals, finding a significant protective effect with a combined effect value of -0.66.

The paper identifies GSK3 inhibitors as synthetic lethal with cohesin mutations, revealing Wnt pathway activation as a therapeutic target in cohesin mutant cancers.

This study shows that DYNC1LI2 restores endolysosomal dynamics and cellular homeostasis in cystinosis by rescuing LAMP2A localization and reducing ER stress and mitochondrial fragmentation.

This study identifies a protoporphyrin derivative that inhibits entry of enveloped viruses by targeting viral lipids, showing broad antiviral activity in vitro and in vivo.

This study investigates the molecular mechanisms of 2019-nCoV binding to human ACE2 and its evolutionary advantages over SARS-CoV using computational methods.

This study evaluates the binding of ritonavir, lopinavir, and darunavir to SARS-CoV-2 proteases using molecular modeling, finding that ritonavir and lopinavir inhibit CEP_C30 more effectively than darunavir inhibits PLVP.

This paper introduces a method to correct missing-wedge artifacts in filamentous tomograms using template-based constrained deconvolution, improving automated segmentation of structures like actin-filament bundles.

This paper develops a framework for glomerulus segmentation in kidney histopathology images using Faster R-CNN and U-Net with weakly supervised training.