J. Sun

This study determines the cryo-EM structure of human CaV2.3 channels and identifies key residues and interactions involved in channel gating and inactivation.

The paper uses genome and transcriptome data to resolve the phylogeny of chitons, supporting that shell eyes originated in Schizochitonoidea and evolved secondarily in other genera.

PlantServation uses machine learning to analyze field images and estimate anthocyanin content in Arabidopsis, revealing seasonal fluctuations influenced by environmental factors.

This study shows O-GlcNAcylation of YTHDF1 enhances its cytosolic localization and promotes colorectal cancer by increasing c-Myc expression.

This study uses confocal reflectance microscopy to map collagen fiber organization in porcine vitreous, revealing fiber density variations and poor alignment.

This study identifies two benzophenanthridine derivatives with potent anti-Mtb activity, effective against multidrug-resistant strains and comparable to rifampicin.

This study links nematode entry into beetles to programmed tracheal development, showing gene expression changes and hormone activation facilitate nematode transmission.

The paper identifies SLK splicing dysregulation in cancers, showing SLK-L promotes metastasis while SLK-S inhibits it, with Rbfox2 regulating this splicing event.

This study identifies 16 cuproptosis-related molecules and develops a scoring system to predict prognosis, tumor immune microenvironment, and immunotherapy response in colorectal cancer.

This study investigates the interactions between cisplatin and E-cadherin using fluorescence spectroscopy and AFM, revealing strong binding and structural changes.

This study compares symbiont population differentiation in deep-sea mussels with different ecological niches, finding that habitat homogeneity and mixotrophy reduce geographic structuring of symbiont strains.

This study identifies steroidal glycoalkaloids (SGAs) as contributors to anthracnose resistance in tomato, showing higher SGA accumulation and gene expression in resistant fruit.

This study identifies TMEM65's role in mitochondrial calcium regulation, showing its loss causes mitochondrial disease and suggesting therapeutic targeting of mitochondrial calcium as a potential treatment.

This study compares Babesia and Plasmodium genomes and gene expression to explain why Babesia is not killed by artemisinin, finding differences in haem synthesis, iron utilization, and gene expression.

The paper identifies KsgA's role in ribosome assembly by using cryo-EM and machine learning to show it proofreads and disassembles immature ribosomal subunits, improving assembly fidelity.

This study identifies EhDUF2419 as the enzyme enabling Entamoeba histolytica to salvage queuine from gut bacteria, which is essential for tRNA modification and oxidative stress resistance.

This study shows that the adipose-neural axis contributes to cardiac arrhythmias through leptin-induced activation of sympathetic neurons and subsequent effects on cardiomyocytes.

This study uses single-cell RNA sequencing to show that aged alveolar macrophages exhibit a senescence-like phenotype linked to reduced CBFβ expression and impaired self-renewal.

This study investigates the role of Q-tRNA modifications in inflammatory bowel disease, finding reduced QTRT1 expression and altered junction proteins in IBD patients and models.

This study shows that intestinal vitamin D receptor deficiency promotes breast cancer by causing gut dysbiosis, increased inflammation, and microbial translocation.

This study examines the gut microbiome of superworms fed polystyrene, identifying bacteria and enzymes involved in polystyrene degradation and highlighting negative impacts on microbial diversity.

This study constructs a spatiotemporal MRI atlas of fetal brain development in Chinese fetuses, revealing a central-to-peripheral cortical growth gradient and dynamic structural asymmetry.

This study shows that suppressing CMTM6 in tumors or hosts enhances anti-tumor immunity independently of PD-L1, suggesting CMTM6 as a target for gene therapy.

This paper uses machine learning to discover three new senolytic compounds by screening FDA-approved drugs and clinical candidates.

This study determines cryo-EM structures of LRRK2-Rab29 complexes, revealing the structural basis of LRRK2 membrane recruitment and activation, and identifies potential targets for Parkinson's disease treatment.

This study shows that venous clamping in rats causes severe kidney tubular injury due to red blood cell extravasation and uptake, which is absent in blood-free kidneys.

This study shows that mTKIs like sorafenib downregulate DDX5, leading to activation of Wnt/β-catenin and non-canonical NF-κB pathways, which enable ferroptosis escape and mTKI resistance in liver cancer.

The paper shows that hypoxia induced by pinewood nematode (PWN) loading increases tracheal elasticity and ECM thickness in beetles, enhancing PWN transmission.

This study shows that music increases protein content and photosynthetic efficiency in duckweed and activates Glu and Ca signaling, with transcriptomic changes linked to metabolic pathways.