J. Sun

This study shows that intestinal epithelial Axin1 deficiency reduces susceptibility to colitis by altering gut microbiota composition and Paneth cell function.

This study shows that alveolar regeneration after viral infection occurs independently of tuft cells, with ectopic basal progenitor cells generating alveolar epithelial cells through distinct differentiation paths.

This study shows that modifying CAR activation motifs improves anti-tumor efficacy in solid tumors despite reduced in vitro cytotoxicity.

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

This study combines emodin with low-frequency low-intensity ultrasound to treat osteomyelitis by enhancing antibacterial and anti-biofilm effects through sonoantimicrobial chemotherapy.

This study identifies PIMT as a suppressor of endothelial activation and vascular inflammation by methylating TRAF6, inhibiting its function and reducing ICAM-1 expression.

This study uses longitudinal metabolomic analysis to show that butyrate treatment in ALS mice alters metabolites, inflammation, and microglia, suggesting potential therapeutic applications.

The paper constructs an ordered mutant collection of Bacteroides thetaiotaomicron using transposon-insertion and barcode sequencing, identifies factors limiting coverage, and demonstrates phenotypic screening for growth defects and cell shape changes.

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

This study investigates the effect of moxibustion on colorectal cancer liver metastasis using animal models, finding reduced metastasis rates and identifying potential molecular targets.

This study shows that combining mRNA vaccines targeting the SARS-CoV-2 spike and nucleoprotein proteins enhances protection against the delta variant in animal models.

The paper identifies and validates genes involved in metabolite damage repair and preemption in the minimized Mycoplasma JCVI-Syn3A genome and extends its metabolic map.

This study shows RAD51 forms distinctive nuclear zones to facilitate homologous recombination by bridging damaged and intact DNA during repair.

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

This paper develops a novel circular mRNA (C-RNA) platform for cancer therapy, showing it enhances anti-tumor immune responses and improves protein expression through optimized formulation.

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

This study identifies LRRC23 as a conserved component of the radial spoke complex in mouse sperm, essential for flagellar motility and male fertility but not ciliary function.

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

This study identifies OsMADS58's role in stabilizing gene regulatory circuits during rice stamen development using CRISPR knockout and transcriptomic analysis.

This study determines the cryo-EM structure of VAR2CSA and its complex with CSA, revealing conformational changes and identifying mutations that abolish CSA binding and cytoadherence to placental and tumor cells.

This study shows that human cord blood-derived stem cells suppress B-cell activation via a Gal-9-dependent cell contact mechanism and affect calcium levels and signaling pathways.

The paper identifies TOP1 inhibitors as therapeutic agents for neuroinflammation and develops a DNA origami nanosystem for targeted delivery to myeloid cells.

The paper uses genetically diverse mice to model varied innate immune responses to SARS-CoV-2 infection, showing differences in survival, viral replication, and cytokine profiles.

This study identifies three new viral families associated with Asgard archaea in deep-sea sediments, showing they are prokaryotic-like viruses with no clear evolutionary link to eukaryotic viruses.

This study identifies genetic transcript regulation and cyclohexane release as factors enhancing duckweed regeneration through callus formation.

This study shows that microbiome dysbiosis in ALS mice precedes motor neuron degeneration and affects intestinal neuromuscular function, with interventions improving symptoms.

This paper shows that SARS-CoV-2 triggers mast cell degranulation, leading to alveolar epithelial inflammation and lung injury, and that MC stabilizers can reduce these effects.

This paper identifies that NS5A of CSFV inhibits NF-κB signaling by degrading NEMO and blocking its k63-linked polyubiquitination.