L. Guo

The paper compares metatranscriptomic responses of Arabidopsis to endophytic and pathogenic Fusarium strains, revealing transcriptional plasticity and differential gene regulation.

This study shows human microglia can be reconstituted in the brain of hu-BLT mice with hIL34 transgene and support HIV-1 infection, highlighting their role in CNS HIV-1 pathogenesis.

This study identifies EGT2 as a conserved gene regulating root growth angle in barley and wheat through gravity response, with potential for crop improvement.

This study investigates the effects of carbon, nitrogen, phosphorus, and potassium on flowering and fruiting of Glycyrrhiza uralensis, finding that higher levels of C, P, and K benefit flower bud differentiation, while excessive N is detrimental, and optimal N and K levels at the filling stage improve seed setting and filling.

This study profiles protein crotonylation in different mouse pluripotent states, identifying 3628 sites and showing that crotonyl-CoA promotes proteasome activity and delays differentiation.

This study analyzes cerebrospinal fluid from healthy pregnant women and finds no evidence of a detectable microbial community after accounting for contamination.

This study engineers a trimeric ACE2 protein that binds the spike protein with high affinity, inhibiting SARS-CoVs and mutants by locking the spike in a 'three-up' conformation.

This study shows that a small morphotype of Cryptococcus neoformans, called 'seed' cells, is critical for extrapulmonary organ entry and is induced by environmental factors like phosphate.

This study shows that glioblastoma uses fatty acids and ketone bodies for growth, and that ketogenic diet therapy does not effectively inhibit tumor progression.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

The paper uses digital spatial profiling to analyze coronary plaques from HIV-positive and HIV-negative individuals, finding higher CD163 and STING expression in HIV-positive plaques.

This study identifies Na2CO3-responsive proteins and phosphoproteins in alkaligrass, revealing mechanisms for photosynthesis and ROS homeostasis under alkali-salinity stress.

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

This study identifies that mammalian ATG9s bind to LC3 via UIM-UDS interaction to drive autophagosome formation.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

This study establishes a relative adrenal insufficiency (RAI) animal model and shows that glucocorticoid (GC) therapy benefits RAI mice but harms non-RAI mice, supporting a precision medicine approach for sepsis treatment.

The paper investigates auxin and GA signaling crosstalk in wild strawberry fruit initiation, revealing conserved and novel mechanisms through genome editing and network analysis.

This study identifies a partnership between BRD4 and CEBPD that promotes inflammatory SMC state transition and CEBPD transcription in vascular disease.

This study investigates how angioplasty induces epigenomic changes in rats, revealing BRD4 and EZH2's roles in regulating neointimal hyperplasia through histone modifications.

The paper introduces an efficient long fragment editing technique for scarless genome engineering in E. coli, enabling large-scale DNA insertion and deletion with high success rates.

This paper infers dynamic transcriptional regulatory networks in Fusarium graminearum using multi-omic data and a Bayesian network algorithm, revealing condition-specific modules and their associations with phenotypes.

This study identifies miR476a/RFL as a regulator of adventitious root formation in poplar through mitochondrial homeostasis and auxin pathway modulation.

This study identifies a non-genetic mechanism for cisplatin resistance in lung adenocarcinoma involving the integrin β4/paxillin axis and its regulation of USP1 and VDAC1.

This study shows that Arabidopsis PPC2 is essential for growth at low CO2 by linking photorespiratory metabolism with primary metabolism and ABA signaling.

This study shows that inhibiting DOT1L reduces intimal hyperplasia in rat carotid arteries by lowering H3K79 methylation levels.

The paper clones human dental pulp cells to study inter-clone diversity and improves reliability of single-cell origin through a 96-well plate method.

This paper introduces a method to create spatially heterogeneous lung injury in mice, enabling better study of drug targeting and regeneration in lung diseases.

This study characterizes PsBCAT, a branched-chain amino acid aminotransferase from Pseudomonas sp., showing broad substrate specificity and high activity, and demonstrates its application in efficient chiral amino acid synthesis.