L. Zhang

This study shows that clathrin light chains in Arabidopsis interact with autophagy proteins, impairing autophagy and leading to accelerated senescence and immune activation.

This study characterizes two bacterial O-methyltransferases, revealing their broad substrate scope and crystal structures, with implications for biocatalytic applications in drug development.

This paper introduces a hierarchical strategy using CXMS and AlphaFold2 to analyze protein dynamics in vivo, focusing on IDPs and multi-domain proteins.

This study shows that phosphorylation of Y57 in VAMP721 regulates SNARE function by modulating its activity and interaction with cognate partners.

This study examines blaCTX-M gene variants in E. coli from chicken and human sources in Ecuador, finding greater similarity between isolates from a rural community and suggesting potential gene transfer between chickens and humans.

This study uses spatial technologies to analyze high-grade gliomas, revealing distinct tumor niches and immune interactions linked to intra-tumoral heterogeneity.

This study shows that gasdermin D promotes influenza virus-induced mortality by amplifying neutrophil-driven inflammation.

This study identifies TIP1 as a key gene in Arabidopsis that regulates microbiota levels and composition, revealing two classes of autoimmunity: microbiota-dependent and microbiota-independent.

This study shows that c-di-GMP interacts with putrescine via the YcgR receptor to regulate bacterial motility in Dickeya oryzea, with c-di-GMP inhibiting putrescine's effect.

This study identifies ERRs as regulators of autophagy through TFEB activation in cardiomyocytes, suggesting ERR targeting as a therapeutic strategy for heart failure.

Rolosense detects SARS-CoV-2 using a DNA-based motor that stalls in the presence of viral particles, offering a rapid, low-cost, point-of-care diagnostic method.

The paper monitors antibiotic resistance genes in wastewater treatment plants and finds that mass-immigration of bacteria and ARGs from upstream units shapes ARG communities, with stochastic processes dominating their assembly.

This study generates transgene-free canker-resistant citrus plants using Cas12a/crRNA RNP editing, achieving high mutation rates and regulatory approval.

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

The paper introduces DBSN, a deep learning method that enables imaging of multiple subcellular structures using only two fluorescent labels, overcoming spectral overlap limitations.

This study compares multi-omics data across three plant sources of Amomi Fructus to identify genetic and transcriptomic differences, including gene flow and metabolic variation between populations.

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

The paper improves 15N chemical shift prediction by incorporating conformational dynamics from MD simulations, showing better agreement with experimental NMR data at different temperatures.

This paper uses RNA sequencing to classify lung cancer subtypes and identifies drug repositioning opportunities based on lineage-specific responses.

The paper shows that phosphorylation and Lamin B receptor regulate PERIOD protein foci accumulation by modulating the circadian phosphatase MTS and kinase DBT.

This study uses label-free proteomics to analyze mouse astrocytes infected with different stages of Toxoplasma gondii, identifying differentially expressed proteins that reveal host response mechanisms in acute and chronic infections.

This study examines the gut microbiome and antimicrobial resistance gene dynamics before and after enteric infection, finding higher resistance gene diversity during infection and shifts in microbial composition post-recovery.

This study uses phylogenomic analysis of macaque genomes to show that incomplete lineage sorting and ancient hybridization contributed to the radiation of macaques.

This paper investigates the cellular uptake, trafficking, and antisense gene regulation mechanisms of bottlebrush polymer-conjugated oligonucleotides in cancer cells.

This study shows that acetoacetate activates human neutrophils via FFA2R, affecting cAMP levels, calcium signaling, ROS production, and migration.

The paper uses metagenomics to identify 22 RNA viruses in ticks from northeastern China, revealing novel species and highlighting public health risks from emerging tick-borne viruses.

This paper develops cholesterol-deficient T cell membrane-coated nanoparticles to deliver STING agonists for tumor immunotherapy, showing improved blood clearance evasion and enhanced antitumor effects.

This paper investigates the role of MoCK2 in rice blast fungus metabolism and mitochondrial protein import, finding it affects acetyl-CoA production and mitochondrial function essential for pathogenesis.

Disruption of glucosinolate catabolic genes, BGLU28 and BGLU30, in sulfur-starved mature Arabidopsis impaired growth, affected glucosinolate distribution, and altered transcriptional profiles.

This study shows that Leptospermum extract (QV0) reduces pleural mesothelioma tumour growth in vitro and in vivo by inducing mitochondrial dysfunction and apoptosis without adverse effects.