L. Zhang

The paper shows that mucins from the laminated layer of E. granulosus are captured by Kupffer cells via Clec4F, highlighting a mechanism for host clearance of parasite-derived materials.

A synthetic ERRα agonist activates an acute aerobic exercise genetic program in skeletal muscle, enhancing exercise capacity and mitochondrial function in mice.

This study shows that KMT2D regulates thymic egress by affecting maturation and integrin expression in T cells, leading to immune dysfunction in Kabuki syndrome type 1.

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

This study engineers a plant enzyme to increase the production of methylated flavonoids in engineered microbes.

This paper identifies and characterizes a novel oxidase gene cmO in Sphingomonadaceae that mediates chloramphenicol and thiamphenicol resistance through oxidative inactivation.

This study shows that PEGSerp-1 treatment reduces inflammation and improves outcomes in SARS-CoV-2 infected mice by modulating immuno-thrombotic responses.

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

This study identifies GPR183 as a key receptor guiding CD301b+ cDC2 to a TSLP-dependent survival niche in the lung adventitial cuff.

This paper introduces a method to locate cellular contents during cryoFIB milling using secondary-electron imaging, demonstrating its feasibility across different instruments and conditions.

The study identifies RBP45d as a key regulator of 5' splice site selection in Arabidopsis by binding to intronic U-rich elements and interacting with PRP39a.

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

The paper shows cardiolipin regulates Complex II assembly and stability in macrophages, linking it to inflammatory metabolic reprogramming.

This paper develops a transparent active ECoG array using ZnO-TFTs for electrophysiological monitoring, enabling simultaneous optical and MRI-compatible brain signal recording.

This paper identifies FcγRIIB-mediated capture of antibody-coated bacteria by liver sinusoidal endothelial cells as a mechanism for superior vaccine efficacy.

The paper reports the cryo-EM structure of the RNF complex in Azotobacter vinelandii, revealing its role in transferring electrons from NADH to ferredoxin using the proton motive force.

This paper identifies phthiocerol dimycocerosate (PDIM) as essential for Mycobacterium tuberculosis antibiotic tolerance under nutrient starvation, suggesting PDIM synthesis as a target to enhance antibiotic efficacy.

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

This study examines genomic heterogeneity and stability in pancreatic cancer organoids using single-cell whole-genome sequencing and transcriptomic analysis.

This study identifies miR-144 as a regulator of adipogenesis by mediating the formation of the C/EBPα-FoxO1 protein complex, which influences AdipoQ expression and adipocyte differentiation.

This paper develops a long-circulating molecular brush to enhance aptamer stability and bioactivity in vivo.

This study investigates TANGO2 deficiency in iPSC-derived cardiomyocytes and fibroblasts, finding no defects in mitochondrial OXPHOS function under baseline or fasting conditions.

This study investigates rhubarb's effects on constipation-induced inflammation, gut microbiome, and metabolism in mice, showing improvements in cytokine balance, microbial diversity, and fatty acid metabolism.

This study shows Ralstonia solanacearum alters root development in Arabidopsis through auxin-dependent and independent mechanisms, including promoting xylem differentiation and root hair formation.

This study determines the cryo-EM structure of TMEM87A, revealing its domain arrangement and suggesting a role in membrane trafficking rather than ion channel or GPCR function.

This study examines how seasonal hydrological changes affect the transition of antibiotic resistance genes between particle-attached and free-living lifestyles in a deep freshwater reservoir.

The paper identifies G42 as a lysosomal calcium mobilizer that inhibits autophagy and viral infections by alkalizing lysosomal pH and blocking autophagosome-lysosome fusion.

This study investigates the role of Esp in strengthening enterococcal biofilms under acidic conditions, showing that Esp unfolding and aggregation enhance biofilm stability.

This study shows that loss of DNMT3A causes obesity by disrupting adipogenesis and triggering inflammation in adipose tissue.