L. Zhou

This study identifies serum albumin concentration as a tertiary risk factor for dialysis-related amyloidosis, showing that maintenance dialysis improves outcomes by increasing serum component concentrations.

Unadjuvanted intranasal spike vaccine booster generates broad sarbecovirus protective mucosal immunity in a preclinical model.

This study identifies NSP2-induced repression of Ifnb1 mRNA translation as a mechanism by which SARS-CoV-2 suppresses IFN-β production.

The paper uses genomic data to show that natural selection and demographic history jointly shaped the genetic structure and contact zones in Norway spruce during post-glacial recolonization.

The paper reports the cryo-EM structure of the budding yeast Smc5/6 holo-complex, revealing its architecture and interactions between subunits.

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

The paper investigates nonenzymatic RNA copying using 2AI-bridged dinucleotides, finding that sequence-dependent differences in binding and reaction rates limit template copying.

The paper examines ER exit sites in Drosophila, finding pre-cis-Golgi regions and pearled tubes but no megacarriers for ER-Golgi transport.

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.

The paper identifies CB002 analogues that restore p53 signaling and target an S-phase checkpoint in p53-mutated tumors, inducing apoptosis and reducing proliferation without harming normal cells.

This study shows that EGCG from green tea inhibits SARS-CoV-2 and its variants by blocking spike protein binding to ACE2 receptors.

This study shows BRAF inhibitors reprogram cancer-associated fibroblasts to promote matrix remodeling and resistance to therapy in melanoma by enhancing β-catenin signaling and POSTN expression.

This study identifies Nse5/6 as a negative regulator of Smc5/6 ATPase activity in S. cerevisiae by showing it suppresses ATP turnover through binding to the complex head-end.

This study shows Bub1 and the CENP-U complex redundantly recruit Plk1 to kinetochores, ensuring accurate chromosome segregation, and suggests potential therapeutic targets for cancer cells with Bub1 or CENP-U mutations.

This study shows that TTP overexpression prevents gastric inflammation and metaplasia in mice by suppressing innate immune genes, with partial protection linked to Tnf suppression.

FOD-Net improves angular resolution of FOD images from clinical dMRI data to match research-quality data, enabling better tractography and connectome reconstruction.

This study uses AFM-IR spectroscopy to show that phospholipids differentially affect the secondary structure of α-synuclein oligomers, with phosphatidylcholine and phosphatidylserine leading to distinct structural outcomes.

This study determines the structure of the Bax core dimer and shows it forms part of the mitochondrial pore wall during apoptosis.

This paper introduces 2bRAD-M, a low-cost metagenome-sequencing method that enables species-level microbial profiling of low-biomass and degraded samples with high accuracy.

This paper identifies ZmLARP6c1 as a pollen-specific RNA-binding protein in maize, showing its role in competitive pollen tube growth through a mutant analysis.

This study shows that deleting Letmd1 in mice causes mitochondrial dysfunction in brown adipose tissue, leading to thermogenesis disruption and metabolic disorders.

The paper determines the cryo-EM structure of the human R2TP-TTT complex and shows how TTT recruits TOR to R2TP while regulating its chaperone activity.

The paper develops a nanopore sequencing method to identify STIs and detect antimicrobial resistance in clinical samples.

This study shows that combining CDK4/6 and HSP90 inhibitors reduces HIF1 expression and cancer cell viability, including in Rb-deficient cells.

The paper develops a droplet printing method to study bacterial ecology by manipulating spatial arrangements of E. coli strains and shows how micron-scale structure affects competition and coexistence.

The paper shows that rapid apoptosis in Aedes aegypti midgut cells limits DENV-2 and ZIKV proliferation, suggesting apoptosis as an antiviral defense mechanism.

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

This study shows vitexin inhibits melanoma cell invasion and metastasis by targeting the STAT3 signaling pathway.

This study identifies lncRNA-RMST as a SOX2 co-regulator that modulates miR-1251 expression, influencing cell proliferation and migration in Hirschsprung's disease.