M. Wang

An oral mRNA vaccine using bovine milk-derived exosomes encoding SARS-CoV-2 RBD induces neutralizing antibodies in mice.

This study shows that inhibiting POLQ in CHO cells enhances CRISPR/Cas9-mediated precise genome editing by increasing knock-in efficiency and reducing random integration.

This study uses super-resolution microscopy to analyze platelet morphology, ultrastructure, and function in acute ischemic stroke patients, revealing structural and functional changes and demonstrating the utility of the technique for assessing antiplatelet drugs.

This study shows that new SARS-CoV-2 BQ and XBB subvariants have significantly reduced neutralization by vaccines and monoclonal antibodies, suggesting a threat to current immunity.

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

The paper investigates RdDM-independent functions of MORC proteins, showing they compact chromatin and repress gene expression by reducing TF accessibility, especially under stress.

The paper identifies multiple proteins that can silence genes in Arabidopsis through various epigenetic mechanisms and develops a machine learning model to predict silencing efficacy.

This study shows that P. multocida infection increases respiratory epithelial permeability in mice and humans by activating the HIF-1 and VEGFA signaling pathways.

This study develops a multimeric antibody platform (Multabody) that enhances neutralization potency and breadth against SARS-CoV-2 and its variants through avidity and multi-specificity.

This study shows APOBEC3B edits R-loops at ER enhancers, leading to DSBs that contribute to genomic instability in breast cancer.

This study reveals a comprehensive allergen profile of Tyrophagus putrescentiae using multi-omic approaches, identifying 37 allergen groups and five novel allergens.

The paper introduces the JGI Plant Gene Atlas, a resource that improves gene function annotations by analyzing transcript abundance across 18 species and 604 tissues, identifying 64,620 genes with unknown functions.

The paper investigates how crossover (CO) distribution in maize becomes U-shaped during meiosis, finding that chromatin state, not DNA methylation or sequence polymorphism, shapes the final CO landscape.

The paper uses human pluripotent stem cell-derived lung and heart models to identify antiviral compounds with distinct profiles, highlighting the need for multi-organ testing in SARS-CoV-2 treatment.

This study shows that ASF1 in Arabidopsis preferentially interacts with the HIRA complex for H3.3-H4 deposition, affecting chromatin structure and gene regulation.

This study investigates reductive genome evolution in Cardinium endosymbionts, identifying endogenous plasmids and their enzymes as drivers of genome reduction.

This study evaluates the neutralization resistance of SARS-CoV-2 Omicron subvariants BA.4.6, BA.4.7, and BA.5.9 to antibodies, finding increased resistance to certain monoclonal antibodies and vaccine-induced sera.

The paper develops a theoretical framework and validates it experimentally to show that even allocation of benefits stabilizes microbial communities engaged in metabolic division of labor.

This study identifies three natural compounds that inhibit SARS-CoV-2 PLpro by binding to the ISG15/Ub-S2 allosteric site, showing antiviral activity and potential for drug design.

This study identifies intrinsically disordered regions in BRCA1/BARD1 that mediate chromatin recruitment and ubiquitylation, enhancing DNA damage repair and transcriptional regulation.

The paper investigates how strain dropouts in the gut microbiome affect community metabolism and host physiology, finding that functionally redundant strains can have significant impacts outside their niche.

This study reconstructs the skull of an Early Cretaceous bird to understand the evolutionary development of cranial kinesis in early avialans.

The paper uses machine learning to identify key chromatin features that determine meiotic recombination sites in plants, finding that three features can predict crossover sites with 90% accuracy.

This study shows that brassinosteroids promote tomato fruit ripening by enhancing ethylene production and carotenoid accumulation through the SlBZR1 transcription factor.

This study generates genetically engineered goats expressing a domain fusion TLR2-4 receptor to enhance autophagy-dependent clearance of Staphylococcus aureus in macrophages.

This study shows membrane curvature regulates Piezo1 distribution in live cells, with Piezo1 depletion from curved protrusions and enrichment in invaginations, and activation reduces filopodia formation.

This paper introduces a threshold-aware method for optimizing adaptive cancer therapies under stochastic tumor evolution, improving success chances within a drug budget.

This paper introduces a new eccDNA purification method and a full-length sequencing approach to improve eccDNA analysis and mapping.

This study shows that the adipose-neural axis contributes to cardiac arrhythmias through leptin-induced activation of sympathetic neurons and subsequent effects on cardiomyocytes.

This study identifies TRIM21 as a regulator of PKR-mediated protein translation by modulating PP1 ubiquitination and eIF2 dephosphorylation, revealing its role in antiviral defense and potential therapeutic applications.