M. Wang

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

This paper identifies an inhibitor/anti-inhibitor system in Pseudomonas aeruginosa that regulates the lytic transglycosylase MltF, affecting antibiotic resistance and cell wall homeostasis.

This study shows that endothelial SARS-CoV-2 infection does not significantly contribute to COVID-19-associated vascular pathology in mice.

This study shows that combining proguanil and chlorhexidine with clarithromycin or rifampicin enhances antibacterial activity against Acinetobacter baumannii in vitro and improves treatment outcomes in mice.

The paper investigates the role of TERT promoter mutations in dysplastic nevi and their association with senescence mechanisms and progression to melanoma.

This study develops bottle-brush polymers optimized for tumour targeting, showing improved delivery efficacy and reduced toxicity in various tumour models.

This study develops a resistance-resistant antimicrobial by inducing catastrophic DNA damage in intracellular mycobacteria through a hybrid organoruthenium-natural product that manipulates bacterial ROS production.

This study maps the 3D chromatin structure of rhabdomyosarcoma subtypes using Hi-C, revealing structural variations and gene regulatory patterns.

This paper identifies synergistic drug combinations in AML using high-throughput methods and open-source tools, revealing synergies affecting histone H3 lysine-27 modification.

This study shows that reduced RPL22 expression in hematopoietic stem cells promotes leukemia by altering metabolism and increasing lipid synthesis via Lin28b.

This study uses single-nucleus RNA sequencing to create a cell atlas of deep-sea mussel gills, revealing cell types and their roles in supporting chemosynthetic symbiosis and environmental adaptation.

This study examines bacterial community structure in intertidal sediments of Jiaozhou Bay, finding that sandy sediments have more species involved in community building and that temporal changes have a greater impact on bacterial communities than on gene families.

The paper identifies 12 transcriptional gene programs in CD4+ T cells from autoimmune diseases and shows their utility in disease characterization and prediction.

SeMOE enables absolute glycan quantification and visualization through selenosugar-based metabolic oligosaccharide engineering, with demonstrated anti-cancer potential.

This study uses human hepatic organoids to identify pro-fibrotic signaling pathways and potential therapies for liver fibrosis.

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

This study develops a base-editing strategy to correct the ABCA4 mutation in mice, non-human primates, and human retinal tissue, achieving high editing rates in vivo.

This study shows that gemcitabine plus nab-paclitaxel reduces tumor burden and prevents muscle and cardiac wasting in a murine model of pancreatic cancer cachexia.

This study shows that chromosomal instability in cancer cells can enhance macrophage-mediated immune responses and induce a broad anti-tumor IgG response, improving survival when combined with CD47-SIRP checkpoint disruption.

The paper shows that SNC1, an immune receptor, guards ADR1-L1 and ADR1-L2 from bacterial effector suppression, enabling plant immunity through sequence diversification and a layered defense system.

This study investigates the effects of bovine milk-derived exosomes on human skin anti-aging, showing they enhance moisture retention and reduce wrinkles while being safe for use.

This study shows Lactococcus G423 improves broiler growth and survival by altering gut microbiota and metabolites, while antibiotics negatively affect microbiota.

This study characterizes the catalytic and non-catalytic mechanisms of SUV420H1 by determining cryo-EM structures and showing its role in DNA accessibility and chromatin condensation.

This study identifies amphipathic helical peptides as a novel adjuvant that enhances immunogenicity of recombinant proteins by promoting antigen delivery into the cytosol without inducing inflammation.

The paper correlates physicochemical properties of an rAAV vaccine candidate with its biological potency, showing links between physical stability, transduction efficiency, and immunogenicity.

The paper describes a multiplex digital PCR assay for detecting genetic variants and fusions in NSCLC, showing high accuracy and utility in challenging samples.

The paper shows that physiological stress in Salmonella leads to a subpopulation with reduced rRNA content, identified through rRNA-FISH and transposon screening.

The paper identifies keystone taxa in activated sludge microbial communities that enhance stability but reduce function, highlighting the trade-off between stability and performance.

The paper uses live-cell ChReporters to show that Myosin-II suppression in confined mitosis increases heritable chromosome loss, independent of spindle assembly checkpoint in 3D and 2D.

This study creates a spatial transcriptomic atlas of tomato callus during shoot regeneration, identifying cell types and developmental trajectories.