Q. Huang

This study identifies HAUSP as a deubiquitinase that stabilizes SOX2 in glioma stem cells, maintaining their self-renewal and tumorigenic potential, and shows that targeting HAUSP can enhance GBM treatment.

This study uses Raman spectroscopy and DFT calculations to distinguish three optical isomers of all-trans astaxanthin based on differences in Raman band intensities.

This study shows YAP1 promotes breast cancer metastasis by enhancing TIAM1 expression through its enhancer, leading to increased RAC1 activity and invadopodia formation.

This study uses single-cell RNA sequencing to identify cell type-specific molecular changes and altered intercellular communications in COPD, linking them to alveolar epithelial dysfunction.

The paper updates the Progenetix resource with expanded cancer copy number variation data, improved quality, and enhanced data access tools.

This study introduces a multi-enzyme directed evolution model to improve screening throughput and efficiency, revealing convergent evolution in two cytochrome P450 enzymes with distinct active sites achieving similar functions.

This paper uses synchrotron SAXS to investigate the structural behavior of oat protein isolate in aqueous solutions, revealing disk-shaped structures at low concentrations and rodlike aggregates at higher concentrations.

This paper identifies a gut microbial peptide that mimics an insulin epitope and contributes to Type 1 Diabetes pathogenesis by triggering immune cross-reactivity and accelerating disease onset in mice.

The paper develops a mechanistic model to predict how temperature and humidity affect the inactivation rate of SARS-CoV-2 and other enveloped viruses.

The paper observes mitochondrial biogenesis as an early event preceding radiation-induced apoptosis in living cells using a dual fluorescence reporter system.

This study shows that altering energy metabolism via IDH gene knockdown affects foraging behavior in termites, with social context modulating these effects.

This study reveals how target RNA binding regulates Cmr-β complex activities through conformational changes, enabling immune responses against genetic invaders.

The paper analyzes synonymous sites in SARS-CoV-2 genes to assess translational efficiency trends and their implications for viral adaptation and epidemic growth.

This study shows that Bcl6 deletion in Treg cells reduces tumor growth by impairing their suppressive function, and increased Bcl6 expression is linked to poor cancer outcomes.

This study compares gut bacterial microbiota of two fruit-feeding moths from different host plants and locations, finding shared bacterial genera and stability within species despite dietary variation.

This study shows that LZTR1 inactivation in glioblastoma stabilizes RIT1, leading to MAPK/ERK pathway activation and promoting tumor growth.

This study shows that USP21 knockout in Treg cells disrupts immune regulation during Schistosoma japonicum infection, promoting parasite survival and altering immune responses while reducing immune pathology.

This study identifies distinct gut microbiota, IgA responses, and plasma metabolite changes in children who develop celiac disease before diagnosis.

This paper develops and validates an LC/MS/MS method to quantify ceramides and dihydroceramides in human serum, revealing unique gestational patterns during pregnancy.

This study examines how human activities alter capybara habitat preferences and explores the potential impact on zoonotic disease transmission, specifically Brazilian spotted fever.

This study uses a mathematical model to examine how immune responses affect phage-antibiotic combination therapy and finds that treatment frequency and dose are critical for effectiveness.

This study shows that Cep57 and Cep57l1 recruit the Cep63-Cep152 complex to mother centrioles, enabling centriole duplication.

This study compares ten CAR signaling domains in Tregs, finding that wild-type CD28 CARs are most effective in suppressing graft-versus-host disease.

This study analyzes genome-wide divergence patterns in two incipient shorebird species with gene flow, finding distinct genomic regions associated with reproductive isolation and adaptation.

This study performs a meta-analysis of copy number variations in primary cutaneous lymphomas to identify genomic imbalances that distinguish subtypes.

The paper shows that mother centrioles are not required for deuterosome formation and function during basal body amplification in multiciliate cells.

This study investigates the structural interactions of Influenza A Virus M1 protein with lipid membranes using experimental and theoretical methods, revealing details on membrane association, oligomerization, and structural changes upon binding.

The paper shows that signal peptide hydrophobicity can compensate for loss of twin-arginine motifs in Tat substrate targeting, and that Sec signal peptides can also use Tat pathways.