S. Chen

The paper develops a scRNA-seq pipeline to characterize AAV tropism and transcriptional responses at single-cell resolution, revealing cell-type-specific targeting and gene expression changes.

This paper introduces Deep-SMV, a deep learning-based method for super-resolution microbubble velocimetry that directly outputs blood velocity maps without requiring microbubble localization.

This study characterizes morpho-functional traits in mesophotic corals, finding that mesophotic morphotypes optimize light capture and photosynthesis under low-light conditions.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

This study identifies genomic diversity and degradation pathways for N,N-dimethylformamide (DMF) by analyzing 20,762 genomes, revealing plasmid-mediated degradation and anaerobic potential for methane production.

The paper introduces JAMMIT, an algorithm that identifies three immune-related immunophenotypes common to 29 solid tumors using TCGA data.

This study identifies how monocot DCL3 and DCL5 proteins evolved distinct substrate specificities through mutations in their PAZ domains, leading to specialized siRNA production.

This study identifies WAPO-A1 as the causal gene for a QTL affecting spikelet number per spike in wheat and shows that the H2 haplotype significantly increases grain yield.

This study shows that loss of E-cadherin in adult mouse lung epithelium causes emphysema and airway disease, suggesting a causal role in COPD.

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

This paper designs a trimeric RBD vaccine candidate with mutations from multiple SARS-CoV-2 strains, showing broad neutralization against variants including Beta and Kappa.

This study shows that blocking Gi/o-GPCR signaling inhibits HER2-driven breast cancer growth and improves HER2-targeted therapy effectiveness.

The paper shows that high-affinity, neutralizing antibodies against SARS-CoV-2 can be produced without T follicular helper cells through alternative pathways.

This study identifies Reg4 as an antimicrobial peptide that combats Salmonella Typhimurium by binding flagellin and inhibiting bacterial motility, adhesion, and invasion.

The paper identifies DIR1-dependent molecular changes in guard cells during systemic acquired resistance using multi-omics, revealing two 18C fatty acids as potential SAR-related molecules.

This study investigates SARS-CoV-2 infection in placentas from infected pregnant women, finding that the virus infects syncytiotrophoblast cells and triggers maternal immune cell infiltration.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

This study investigates gene expression heterogeneity in the multinucleated slime mold Physarum polycephalum, showing region-specific transcriptional responses and nuclear specialization without cellular compartmentalization.

This study uses long-read sequencing to show DNA methylation affects pre-mRNA splicing, poly(A) tail length, and gene silencing in Arabidopsis.

This study shows that cavefish enhance lipogenesis via upregulated Pparγ to store more fat, aiding adaptation to nutrient scarcity.

The paper defines and extends the near-infrared biological window for improved in vivo fluorescence imaging, proposing new regions and demonstrating enhanced imaging capabilities.

The paper analyzes SARS-CoV-2 mutations and co-mutations, suggesting Canidae as a possible host for the B.1.1.7 variant and showing that co-mutations significantly reduce viral replication.

This study investigates how PAPD5 and PAPD7 stabilize HBV RNA and shows that PAPD5 is dominant in protecting the poly(A) tail, while PAPD7 acts as a backup mechanism.

This study identifies novel SARS-CoV-2 receptors through a CRISPR activation screen, revealing LDLRAD3, TMEM30A, and CLEC4G as functional receptors independent of ACE2.

This study compares the efficacy and affinity of two GLP-1R agonists, P5 and exendin-F1, showing that exendin-F1's lower acute efficacy correlates with sustained insulin secretion and anti-hyperglycaemic effects.

This paper identifies Rab5a as a host factor that RSV activates to suppress IRF1-dependent IFN-λ production, thereby reducing antiviral immunity in airway epithelial cells.

This study identifies a non-canonical role of RNF168 at DNA replication forks, showing it suppresses 53BP1 signaling through PCNA binding, independent of its canonical DSB response function.

The paper identifies ST6GAL1 as a promoter of pancreatic cancer using integrated glycomic and transcriptomic analysis across human and mouse models, showing delayed cancer formation and reduced fibrosis in a novel ST6GAL1 knockout model.