S. Chen

This study shows that cannabidiol inhibits SARS-CoV-2 replication and enhances the host innate immune response in lung cells and human patients.

This study demonstrates that boron-doped bismuth oxybromide rapidly inactivates SARS-CoV-2 under visible light and in the dark, outperforming conventional photocatalysts.

The paper shows host protease neutrophil elastase enhances complement- and antibiotic-mediated killing of bacterial pathogens by disrupting their evasion mechanisms.

This study shows that AMPKγ3 is essential for AICAR-induced glucose clearance and uptake in glycolytic muscle but not for ADaM drug-induced effects or adipose thermogenesis.

The paper analyzes metagenomic data from microbial communities to identify strategies underlying xenobiotic degradation and their ecological interactions.

The paper identifies a CD4+ subpopulation of resident cardiac fibroblasts linked to myocardial fibrosis, showing their transdifferentiation from mesenchymal to lymphoid-like cells via the IL-1β-IL-1R-NFκB pathway.

This study identifies CX-5461 as a TOP2B inhibitor with selective activity in high-risk neuroblastoma but highlights safety concerns due to TOP2B off-target effects.

This study shows that RIPK3 phosphorylation at S165/T166 switches its function from necroptosis to apoptosis, driving corpus luteum regression via PGF2-induced apoptosis.

The paper uses XFM to quantify trace metal storage in Chlamydomonas acidocalcisomes under metal over-accumulation, showing Fe and Cu sequestration and distinct organelle populations.

The paper explains discrepancies in gas vesicle diameter measurements and provides accurate methods using electron microscopy.

This study identifies DDAs as inhibitors of AGR2 and ERp44, showing they induce DR4/5 oligomerization and cancer cell death via disrupting disulfide bonds.

The paper analyzes single-cell transcriptomes during liver transplantation to understand ischemia-reperfusion injury and identifies a protective role for TNIP3 in Kupffer cells.

This study shows that DNA methylation by Type I restriction modification systems in uropathogenic E. coli does not regulate gene expression or virulence, suggesting a 'regulation avoidance' mechanism.

This study shows that TIR signaling is essential for enhancing plant defense during pattern-triggered immunity by activating defense genes and increasing resistance to pathogens.

This study shows that TFH-B cell interactions driven by neoantigens enhance anti-tumor CD8+ T cell responses in lung adenocarcinoma.

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

Overexpressing EiKCS from goosegrass in rice increases polyamine levels and enhances paraquat tolerance through improved antioxidant capacity and photosynthesis.

The paper identifies a conserved glycomic signature in sepsis across different bacterial pathogens by analyzing serum glycomes in mouse models.

This study shows ORMDL1 is upregulated in colorectal cancer and associated with better patient survival.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

This study maps the glycolytic targetome in cancer cells using TRAP, revealing 913 targets and 2,487 interactions for 10 glycolytic metabolites and their functional roles in cancer biology.

This study shows that CSNK1G2 inhibits RIP3-mediated necroptosis, reducing testis aging in mice and conserved in humans.

The paper investigates the structural roles of nucleoporins in the Nuclear Pore Complex (NPC) by degrading individual components and observing the effects on NPC domains.

This study shows that HIV-1 RNA's m6A modifications suppress type-I interferon induction in monocytic cells by evading RIG-I sensing.

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

The paper identifies PF-3845 as a novel inhibitor of Mycobacterium tuberculosis PheRS, showing selectivity over human PheRS and potential as an antibiotic lead.

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.

The paper develops a high-content screening platform to analyze schistosomiasis drug responses and identifies new bioactive compounds.