S. Chen

This study shows that PA200 maintains histone mark stability during transcription and aging by promoting acetylation-dependent degradation of core histones.

The paper traces the evolutionary origin of the F7 chemosensory system in E. coli by analyzing ancestral forms in related bacteria and identifying structural and functional changes.

A hidden layer of host immunity against non-pathogenic microbes leads to plant incompatibility with beneficial rhizobacteria.

This paper develops an oral SARS-COV-2 RBD vaccine using LTB26 adjuvant in mice, showing enhanced antibody production and immune activation through DCs and B cells.

The paper investigates how actin networks adapt to membrane tension during clathrin-mediated endocytosis, finding that actin assembly increases under elevated load to maintain CME robustness.

This paper simulates Ca2+ oscillations in astrocytes under amyloid beta influence in Alzheimer's disease, showing A{beta} alters Ca2+ dynamics through multiple pathways.

This paper introduces a NIR-II cell tracker for real-time monitoring of stem cell behavior in vivo, revealing differential responses to diseased environments and enabling long-term tracking beyond 30 days.

This study shows that keratins K6 and K16 regulate mitochondrial structure, function, and dynamics in keratinocytes, contributing to oxidative stress in pachyonychia congenita.

This study shows that USP21 knockout in Treg cells disrupts immune regulation during Schistosoma japonicum infection, promoting parasite survival and altering immune responses while reducing immune pathology.

The paper identifies 291 protein complexes and 24,092 PPIs in Synechocystis sp. PCC 6803, revealing functional roles of previously uncharacterized proteins and their interactions across biological processes.

This study investigates how ageing affects mouse thymus function, revealing that progenitor cell differentiation is disrupted, leading to impaired T cell selection and self-antigen representation.

This study identifies a non-canonical Notch1 pathway that represses SIRT1 to drive tumor initiation and chemoresistance in breast cancer stem cells.

This study uses a CRISPR screen in mouse Tregs to identify genes regulating Foxp3 expression, finding Usp22 and Atxn7l3 as stabilizers and Rnf20 as a destabilizer.

The paper evaluates how peptide context affects GLP-1R signaling and trafficking, showing differences in agonist-mediated responses based on sequence homology and structural features.

The paper analyzes the genomic and protein structure of 2019-nCoV to determine its origin and infectivity, finding it is a bat coronavirus with weak human ACE2 receptor binding.

This study uses ribbon-scanning confocal microscopy to compare the outflow tract anatomy of human and porcine eyes, finding humans have fewer and larger collector channels.

This study examines how different doses of netarsudil affect intraocular pressure and vessel diameter in porcine anterior segments with and without trabecular meshwork removal.

This paper demonstrates a modular lipid nanoparticle platform for co-delivering siRNA and lipophilic prodrugs to achieve additive anti-cancer effects in vitro.

The paper quantifies epithelial plasticity changes following injury and identifies pharmacologic targets to reverse injury in COPD.

This study identifies MARCH5 as a mediator of NOXA-dependent MCL1 degradation in prostate cancer, enhancing apoptosis when combined with BH3 mimetics.

This study shows that cavefish, adapted to low parasite abundance, have a more sensitive immune system with reduced proinflammatory responses and shifted immune investment to adaptive immunity.

This study identifies six new Neodon species using systematic sampling and low coverage whole genome sequencing, revealing the Qinghai-Tibetan Plateau as the origin and highlighting climate change and geographic isolation as drivers of speciation.

The paper analyzes the intestinal stem cell niche by combining bulk RNA sequencing and scRNA-seq to identify a network of cell types and signals involved in ISC regulation.

The paper investigates mechanisms of EGFR-TKI resistance in NSCLC, showing HER2/HER3 activation and cyclin D1 upregulation contribute to cell survival and resistance.

This paper identifies ASS1 deficiency in rare ovarian cancers and shows that ADI-PEG20 inhibits tumor growth in ASS1-deficient models.

The paper identifies 6mer seed toxicity in viral miRNAs, showing some v-miRNAs kill cells via G-rich 6mer sequences, unlike most cellular miRNAs.

This study develops 3D printed bionic corals that support high-density microalgal growth, mimicking coral structure and function to enhance photosynthesis and bioproduct generation.

The paper identifies lineage-specific activation of HNF4A in gastrointestinal adenocarcinomas through epigenomic and genomic analysis, revealing its role in promoting cancer proliferation.

The paper develops a phage display method to identify highly selective covalent binders, demonstrating its effectiveness with a cysteine protease inhibitor.

This paper improves pulcherriminic acid production in Bacillus licheniformis through multistep metabolic engineering, achieving a record yield of 556.1 mg/L.