S. Chen

This study examines the suction attachment mechanism of Blephariceridae larvae, finding their adhesion is less affected by micro-roughness and their microtrichia enable effective sealing on structured surfaces.

This study shows that cytoplasmic RNAs, particularly tRNAs, regulate cGAS activity by promoting phase separation and modulating its interaction with dsDNA.

The paper develops a BAC-vectored SARS-CoV-2 replicon for antiviral screening and virus-host interaction studies, showing sensitivity to IFN-, remdesivir, and ZAP overexpression.

A single dose of the STARR-based SARS-CoV-2 vaccine LUNAR-COV19 induces protective adaptive immunity in mice, including strong antibody and CD8+ T cell responses, and full protection against viral challenge.

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

This paper validates a method to quantify aristolochic acid DNA adducts in human tissues and applies it to hepatocellular carcinoma samples, finding a low prevalence of adducts.

This study identifies Alectinib as an FDA-approved drug that inhibits SARS-CoV-2 nucleocapsid phosphorylation and viral replication in vitro by targeting host kinases.

The paper identifies public antibody clones in the human repertoire, including virus-neutralizing and anti-PD1 clones, and introduces a tool for analyzing Rep-seq data.

The paper identifies ECA biosynthesis mutations that restore OM barrier function in E. coli tol-pal mutants without restoring lipid homeostasis.

The paper identifies the long noncoding RNA LOUP as a mediator of RUNX1 and RUNX1-ETO effects in t(8;21) AML, showing it promotes myeloid differentiation and inhibits cell growth by regulating PU.1 expression.

This study identifies hyper-truncated glycans on neutrophil myeloperoxidase (MPO) that enhance enzyme activity and inhibition potential, revealing their functional role in immune responses.

This study demonstrates that attenuated Salmonella typhimurium can deliver SARS-CoV-2 spike protein DNA to rats, inducing humoral immunity against SARS-CoV-2.

This study identifies Na2CO3-responsive proteins and phosphoproteins in alkaligrass, revealing mechanisms for photosynthesis and ROS homeostasis under alkali-salinity stress.

This study identifies antiviral compounds that reduce SARS-CoV-2 viral load by counteracting the virus-induced transcriptional landscape, without affecting viral entry or host antiviral response.

The paper examines age-dependent glycomic responses to the 2009 H1N1 influenza virus and links these responses to disease severity in a ferret model.

This paper develops a rapid, low-cost method to detect and quantify SARS-CoV-2 virus particles using nanoplasmonic sensors in microplate readers and smartphone devices.

This study identifies Bcl-XL inhibition as a selective vulnerability of senescent glioblastoma cells following radiation or TMZ treatment.

The paper traces the evolution of sex determination in northern pike, revealing an ancient origin of the master sex-determining gene and recent transitions including Y-chromosome loss.

The paper identifies 8 putative cell wall synthesis genes in Betula pendula using RNA-seq data and constructs a gene co-expression network.

The study identifies redox-sensitive proteins in guard cells during stomatal immunity and characterizes a lipid transfer protein as a redox sensor in plant defense.

The paper characterizes the behavior of a single axis holder during FISE acquisition to balance data quality and speed in cryo-electron tomography.

The paper analyzes antibody responses in convalescent individuals, finding low neutralizing titers but rare potent RBD-specific antibodies with broad antiviral potential.

The paper identifies two SNPs in SARS-CoV-2 genomes prevalent in North America, traces their origin to Europe, and suggests they could be targets for surveillance and treatment.

This paper identifies N-glycosylation as essential for Phytophthora sojae growth and pathogenicity, revealing two distinct N-glycosylation motifs and their functional roles in key life stages.

pegFinder is a web tool that designs prime editing guide RNAs (pegRNAs) for CRISPR prime editing, offering alternative templates and secondary nicking sgRNAs to improve efficiency.

This study identifies a histone-like motif in the yellow fever virus capsid protein that mimics histone H4 and interferes with BRD4-mediated gene regulation, impacting viral replication.

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

This paper identifies and characterizes Fnr paralogs in Paenibacillus polymyxa WLY78, showing their roles in regulating nitrogen fixation and anaerobic metabolism through gene expression changes.

This study uses human pluripotent stem cell-derived colonic organoids to identify drugs that block SARS-CoV-2 infection, finding mycophenolic acid and quinacrine dihydrochloride effective in vitro and in vivo.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.