S. Zhang

This study assesses neutralization of SARS-CoV-2 Omicron subvariants by sera from different vaccination and breakthrough infection cohorts, finding that BQ.1.1 and XBB.1.5 show strong neutralization evasion.

This study shows stroke triggers inflammasome-dependent atherosclerotic plaque rupture, leading to recurrent stroke, and identifies DNA-mediated inflammasome activation as a therapeutic target.

This study identifies Plasmodium EB1's unique MT-lattice binding role in facilitating spindle-kinetochore lateral attachment during male gametogenesis, essential for proper chromosome segregation and parasite transmission.

This paper introduces a fast bioorthogonal reaction system for in-cell spin-labeling and DEER spectroscopy, enabling structural studies of proteins in live mammalian cells.

This study uses spatial transcriptomics to analyze HCC tumors treated with cabozantinib and nivolumab, identifying distinct immune and fibrotic mechanisms linked to response and recurrence.

The paper reports the first experimentally determined structure of CMTM6 and proposes an interaction model with PD-L1, providing structural insights into its role in stabilizing the PD-1/PD-L1 axis.

This study identifies VHL mutation as a driver of CE accumulation in ccRCC through the PI3K/AKT pathway, showing that inhibiting cholesterol esterification suppresses tumor aggressiveness.

This study reveals the cryoEM structures of NTSR1 with and without SBI-553, showing its biased allosteric modulation of G protein and β-Arrestin signaling.

The paper identifies a new CRISPR-Cas12l system from metagenomes, showing it cleaves DNA with a unique PAM and forms a bracelet structure for gene editing.

This study shows PD-L1 maintains IFN-gamma signaling in human pluripotent stem cell-derived macrophages, essential for their development and inflammatory function.

This study identifies a potent ZIKV-neutralizing IgM antibody from a pregnant woman and shows its protective efficacy in mice.

This study uses mid-infrared spectra of milk to establish models for assessing mammalian evolutionary relationships and genetic distances with high accuracy.

This study compares the composition and properties of three mucus types from Cornu aspersum to understand their structure-function relationships and identify novel components.

This paper develops a CRISPR/Cas12a-based genome editing method for bacterial plant pathogens without donor DNA, enabling efficient gene knockout and multiplex editing in Xanthomonas oryzae pv. oryzae.

This study identifies key genetic drivers of ESCC initiation and immune evasion using CRISPR/Cas9 in murine organoids and human scRNA-seq data.

This study identifies PCLAF-DREAM's role in alveolar cell plasticity during lung regeneration and shows a drug candidate can pharmacologically target this process to prevent fibrosis.

This paper proposes a deep learning model for multi-label bacterial classification, showing it is lighter, faster, more accurate, and efficient than existing methods.

The paper provides advanced tutorials for WESTPA 2.0, demonstrating new features for rare-events sampling in molecular simulations.

This study identifies cell lineage as a key determinant of immune response in neuroblastoma by analyzing transcriptional signatures from 498 tumors and showing that mesenchymal-like cells are more immunogenic than adrenergic neuron-like cells.

The paper investigates online trade in jaguar parts across multiple languages and platforms, identifying 230 posts and 125 jaguar parts, with teeth being the most common item.

This study identifies a MYB transcription factor that regulates capsanthin biosynthesis in nonclimacteric pepper fruit, showing its role in carotenoid accumulation and interaction with abscisic acid.

This study shows Leishmania amazonensis suppresses macrophage-regulated cell death pathways to promote chronic infection in vitro and in vivo.

This study identifies 16 cuproptosis-related molecules and develops a scoring system to predict prognosis, tumor immune microenvironment, and immunotherapy response in colorectal cancer.

This study identifies IGF2BP2 as an m6A reader that stabilizes glycolytic transcripts in Leishmania-infected macrophages, promoting HIF-1-independent glycolysis and immune-metabolic reprogramming.

This study shows low molecular weight hyaluronan inhibits lung epithelial ion transport by activating the calcium-sensing receptor, with effects reversed by a CaSR inhibitor or high molecular weight hyaluronan.

This study identifies mitochondrial Ca+2 dysregulation via MAM-STAT3 as a driver of immunosenescence in type A mandibuloacral dysplasia.

This paper engineers a precise adenine base editor, ABE9, with reduced bystander mutations and off-target effects, enabling efficient and accurate A-to-G editing in mouse and rat embryos.

This study identifies ATF3 as a key regulator that preserves skeletal muscle stem cell quiescence by preventing premature activation and maintaining genome stability.

The paper reports cryo-EM structures of FSHR in inactive and active states, revealing a conserved activation mechanism and the role of H6157.42 in agonist selectivity.