W. Li

This study identifies myosin-X and DAAM1 as key factors promoting chiral growth in adherent filopodia, revealing how actin dynamics drive left-right asymmetry in cellular protrusions.

This study identifies how SARS-CoV-2 S protein inhibits type I interferon signaling by interacting with and reducing phosphorylation of STAT1/STAT2, preventing ISGF3 complex formation and ISG expression.

The paper investigates how peptaibol structural diversity in Trichoderma fungi mediates interactions with mycohosts, showing that these compounds are essential for inhibiting saprotrophic fungi.

The paper discovers and evaluates two fully human antibodies that inhibit NKG2A, an inhibitory receptor on NK and CD8+ T cells, enhancing anti-cancer immune responses.

This study identifies introgressed haplotypes from wild sheep species associated with morphological traits in domestic sheep using whole-genome sequencing.

This study shows that Pnpt1 mediates NLRP3 inflammasome activation in macrophages through MAVS and metabolic reprogramming, enhancing IL-1β and IL-18 secretion in sepsis models.

The paper identifies SPTAN1 and RAF1 as genes activated by shear stress during cardiopulmonary bypass, leading to inflammation and cell death through store-operated calcium entry.

This study reports cryo-EM structures of the lentiviral intasome and shows that multivalent interactions are essential for integrase function and virus infectivity.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study shows that actin cytoskeleton signaling via MRTF/SRF modulates circadian clock entrainment by responding to extracellular matrix cues.

This study identifies DNALI1 as a key protein in sperm development, showing its role in the MEIG1/PACRG complex for cargo transport along the manchette and its involvement in sperm individualization.

This study evaluates a multivalent mRNA vaccine encoding SARS-CoV-2 and SARS-CoV receptor-binding domains, showing it induces cross-neutralizing antibodies against multiple variants in mice.

This study identifies bZIP25 and bZIP53 as transcription factors regulating pavement and trichome cell development in Arabidopsis thaliana using single-cell RNA-sequencing.

The paper identifies a novel human antibody VH domain with high affinity for mesothelin and demonstrates its efficacy in both CAR-T cell and antibody drug conjugate formats against mesothelin-expressing cancer cells.

This study identifies a circadian clock control of MRTF-SRF signaling that suppresses beige adipocyte thermogenic recruitment and maintains metabolic homeostasis.

This study identifies WDR5 as an epigenetic regulator that promotes breast cancer growth and metastasis through KMT2-independent translation regulation, suggesting therapeutic strategies targeting WDR5.

The paper quantifies thermodynamic coupling between ligand binding sites in homo-oligomeric proteins using statistical models and native mass spectrometry, revealing large differences in cooperativity.

This study shows that CCR1 activation on respiratory epithelial cells suppresses RSV replication via Gi-mediated inhibition of STAT3 phosphorylation and HSP90 activity, independent of IFN-I.

This study shows that a nutrient-rich diet reprograms intestinal stem cells and lineages, promoting tumorigenesis by altering stem cell function and inducing chronic inflammation.

The paper shows cohesin is essential for meiotic spindle assembly in C. elegans without requiring its role in sister chromatid cohesion.

This paper identifies a small-molecule antagonist targeting the Tudor domain of SMN, disrupting its interaction with RNAP II and mimicking SMN depletion effects.

The paper derives expressions for flux, current, and principal curve in the transition path ensemble using transition path theory and applies them to molecular dynamics simulations of high-dimensional systems.

This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.

This study develops a sequence-based functional metagenomics approach to discover novel CopA genes in environmental microbiomes, identifying 175 new sequences with functional validation.

This study examines structural and biochemical features of Delta and Kappa SARS-CoV-2 variants, showing increased ACE2 binding and antibody escape, contributing to Delta's dominance.

This study identifies Zfp335 as a transcription factor regulating T cell development by controlling TCRβ expression and cell survival through β-selection-dependent and -independent mechanisms.

This study identifies alveolar macrophage reprogramming by ECP that reduces TGF-β bioavailability and prevents BOS by inhibiting CCR2+ monocyte-driven inflammation.

AtGPA1 regulates low-nitrogen stress response in Arabidopsis by interacting with AtNRT1.4 and AtATG8a, affecting nitrate uptake and autophagy.

This study reveals that water-bridged interactions facilitate Ca2+ binding and allostery in calmodulin by reducing energy landscape ruggedness and enabling asymmetric EF-hand responses.