W. Li

The paper presents a nested PCR protocol for detecting CRISPR-induced indels in hexaploid wheat and evaluates existing genotyping methods for their effectiveness in mutation detection.

This study presents the structure of Odinarchaeota tubulin and shows it forms tubules similar to FtsZ, suggesting it is an evolutionary intermediate between prokaryotic and eukaryotic microtubule-forming proteins.

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.

This study shows AMPK and UPR interact via a positive feedback loop in muscle cells exposed to palmitate, with AMPK agonists enhancing UPR gene expression.

This study identifies nanchangmycin as an anti-fibrotic agent that inhibits HSC myofibroblast activity by modulating FYN, FAK, and ERK signaling pathways.

This study shows that fascin promotes lung cancer growth and metastasis by enhancing glycolysis through YAP1-PFKFB3 activation.

This study shows LRP-1 supports tumour cell motility under ischemic conditions by coordinating two distinct signalling pathways involving Hsp90 and EGFR.

This study investigates the effects of HCQ and AZM on iPSC-derived cardiomyocytes, finding that their combination significantly increases cardiotoxicity and electrophysiological dysfunction.

This study shows that a protein-based RBD-C-tag vaccine candidate provides protection against multiple SARS-COV-2 variants in mice.

This paper evaluates four commonly used murine models of atrial fibrillation and finds they do not exhibit authentic AF characteristics, such as micro-reentrant circuits or typical ECG features.

This study identifies an integrin-actin cytoskeleton-MRTF/SRF signaling cascade that modulates circadian clock properties by directly regulating core clock genes.

The paper identifies miR-106b-5p in exosomes from Mtb-infected macrophages that promote Mtb survival by regulating lipid metabolism and apoptosis in uninfected macrophages.

This study characterizes two SARS-CoV-2 antibodies effective against variants, showing their structural basis and mechanisms of neutralization.

This study uses silica-dried leaf tissues for RNA-seq and phylotranscriptomic analysis, showing they are viable for phylogenomic studies with results comparable to liquid nitrogen-preserved samples.

This study shows that 1,25(OH)2D3 reduces hepatic insulin resistance in diabetic rats by improving antioxidant status and enhancing AKT/GLUT2 expression.

This study uses single-nucleus RNA-seq and spatial transcriptomics to identify lineage-specific regulatory changes and candidate therapeutic targets in hypertrophy cardiomyopathy.

This study identifies osteopontin (OPN) released by injured kidneys as a mediator of acute lung injury, showing its role in causing pulmonary inflammation and edema.

The paper measures diffusion coefficients of four enzymes under catalytic conditions and finds no enhanced diffusion.

This study investigates how plasma-activated water (PAW) affects the viability and cellular responses of Fusarium graminearum, finding significant inhibition of microbial activity and damage to cell wall, membrane, and mitochondria.

This study demonstrates that a nanoformulated CAB prodrug (NM2CAB) maintains plasma levels above the inhibitory concentration for up to one year, with sustained drug retention in tissues and macrophages.

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

This study shows that blebbistatin improves iPSC-CM quality during automated patch-clamp procedures, enabling reliable electrophysiological recordings and phenotyping of cardiac channelopathies.

This study uses single-cell transcriptomics to identify novel cell populations and functional differences in human nucleus pulposus during degeneration, revealing potential regenerative and immunosuppressive roles.

This paper introduces MLC-Seq, a method to sequence full-length tRNA isoforms and quantify RNA modifications, demonstrating its application on yeast and mouse tRNAs.

The paper identifies a novel binding site on α-tubulin and shows that cevipabulin binding to this site induces tubulin degradation.

This paper introduces fBSA-Au, a bimodal endocytic tracer for 2D and 3D CLEM, enabling accurate registration of fluorescence to EM data with sub-200 nm precision.

The paper shows that changing two amino acids in S. cerevisiae Ire1 to their S. pombe counterparts makes it promiscuous, revealing that protomer alignment modulates RNA substrate specificity.

The paper uses spatial transcriptomics to analyze lung cancer heterogeneity, identifying gene expression gradients and tumor subclones, and infers metastasis trajectories through pseudo-time modeling.