W. Liu

This paper identifies HeLEA1, a tardigrade LEA protein that acts as a mitochondrial membrane chaperone, improving stress tolerance in yeast by stabilizing lipid packing and reducing surface tension.

The paper identifies IsrR, an sRNA in Staphylococcus aureus, that regulates iron-containing enzyme mRNAs during iron starvation, enhancing bacterial survival in infection.

MCS-DETECT identifies a dual regulatory mechanism for riboMERCs, dependent on RRBP1 and modulated by Gp78 ubiquitin ligase activity.

This study identifies a novel endolysosomal trafficking pathway in Magnaporthe oryzae that facilitates effector secretion and host invasion via Rab7/Retromer/MoSnc1-mediated vesicle transport.

This study identifies PTK7 as a positive allosteric modulator of GPR133 signaling in glioblastoma, showing that their interaction enhances receptor activation and is relevant to tumor pathogenesis.

This study generates and characterizes conditional mutants of yeast scaffolding proteins Boi1/2 and Bem1, revealing their essential functions in polarized growth and cell survival.

This study shows that social isolation in early life disrupts brain development and gene expression in bumblebees, while limited social experience preserves typical patterns.

This study identifies spatially resolved metabolite differences between stable and unstable human atherosclerotic plaques using mass spectrometry imaging and RNA-seq integration.

This study identifies nucleosome binding as a key activator of Sirt7 deacetylase activity, revealing its efficiency and limitations in chromatin context.

The paper identifies GOLVEN10 peptide as a regulator of nodule and lateral root positioning and organogenesis in Medicago truncatula.

This study develops autonomous microinjectors for GI delivery of insulin, showing they can deliver insulin systemically at levels comparable to intravenous administration.

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

This paper demonstrates a method to recycle PCR kits by depolymerizing DNA strands and regenerating nucleotides and primers for reuse.

This study identifies a unique chromatin state in invasive lobular breast cancer (ILC) driven by FOXA1-ER axis, leading to tamoxifen resistance and poor outcomes.

The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.

The paper demonstrates a method to recycle DNA into nucleotides and use them for PCR and qPCR, following a circular economy approach.

This study identifies 6S RNA's role in enhancing rifampicin resistance in Staphylococcus aureus and shows similar effects in other pathogens.

This study identifies PIMT as a suppressor of endothelial activation and vascular inflammation by methylating TRAF6, inhibiting its function and reducing ICAM-1 expression.

This study evaluates nirmatrelvir's in vitro efficacy against SARS-CoV-2 variants, finding it maintains potency against Omicron and other variants.

This study shows that inhibiting TGFβ receptors in tumor-associated macrophages boosts interferon-β production and enhances radiotherapy effectiveness in mouse cancer models.

The paper determines the crystal structure of the Caskin1/CASK complex, revealing the molecular basis of CASK_CAMK domain binding specificity and identifying new potential binding partners.

This study uses mRNA lipid nanoparticles to deliver an active STING mutant to treat STING-deficient cancers, enhancing immune response and inducing cancer cell death.

This paper uses deep learning to segment 15 intracellular compartments from super-resolution images with one dye, achieving high accuracy and faster imaging.

This study shows that SVP interacts with TPL to repress flowering by inhibiting FT gene expression in chrysanthemum and Arabidopsis, highlighting a conserved mechanism across species.

The paper examines the special and general mechanisms of cyanobacterial harmful algal blooms, identifying ecological and evolutionary factors that enable cyanobacteria to dominate under eutrophic conditions.

This study uses first-principles calculations to show rutile TiO2 (110) nanosheets have strong adsorption for DNA nucleobases, exceeding graphene by over 20 times, with implications for DNA sensors and sequencers.

This study investigates how grafting affects anthocyanin synthesis in grapevines by analyzing metabolomic and transcriptomic profiles across different grafting conditions.

This study identifies JM03, a crotamiton derivative, as a small molecule that extends C. elegans lifespan and improves stress resistance by inhibiting OSM-9 and activating SKN-1 signaling.

This study shows azacytidine limits SARS-CoV-2 infection and protects mice by disrupting viral RNA methylation.

The paper reports that a Chlamydia strain from SARS patient autopsy samples inhibits SARS-CoV proliferation in vitro, with inhibitory factors present in both extracellular and intracellular cultures.