W. Yang

This study identifies m6A modification patterns and functions during sexual reproduction in Chlamydomonas reinhardtii, showing its role in regulating microtubule-based processes.

This study identifies PP2A as a phosphatase that dephosphorylates Parkin and ubiquitin, thereby inhibiting mitophagy.

This study identifies Ruminococcus gnavus as a gut bacterium that contributes to IBS-D by increasing serotonin biosynthesis through phenethylamine production.

The paper determines the structure of an IgG-Fc hexamer using cryo-EM, revealing a mutual lock-and-key interaction mode between Fc domains.

This paper develops a biparatopic nanobody with broad neutralization against multiple SARS-CoV-2 variants, including Omicron, showing strong affinity and activity.

This study uses imaging mass cytometry to analyze tumor-immune microenvironments in melanoma patients, identifying distinct microenvironment archetypes linked to responses to anti-PD-1 therapy.

This study shows Epac1 regulates SUMOylation by forming nuclear condensates in response to cAMP, linking stress responses to SUMOylation dynamics.

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

This study identifies two distinct binding modes of RbFox's RNA Recognition Motif that contribute to its high sequence specificity and functional diversity.

The paper identifies a slow conformational switch in pre-miR-21 that regulates its processing efficiency and shows how ligands can modulate this switch.

This paper introduces two deep learning methods for designing proteins with specific functional sites, showing they can generate diverse proteins with desired properties.

The paper applies deep learning to identify anther dehiscence states in cotton to screen for heat-tolerant varieties and support genetic breeding research.

This paper introduces 4DPhenoMVS, a low-cost 3D phenotyping pipeline for tomato plants using multiview images, showing high correlation with manual measurements and environmental impact on growth.

This study identifies a neonatal liver niche that promotes hepatoblastoma metastasis via the Cxcl1/Cxcr2 axis, showing increased tumor aggressiveness and hypoxia in early postnatal models.

The paper identifies nine prevalent SARS-CoV-2-specific CD8 T-cell epitopes in a Norwegian cohort, showing strong correlation between immunoprevalence and immunodominance.

The paper develops SSR markers from drought stress-responsive miRNAs in Dongxiang wild rice and verifies their genetic diversity across DXWR and modern rice varieties.

The paper introduces NoRI, a SRS microscopy method to measure protein, lipid, and water concentrations in tissues, showing cell-specific variations and disease-related changes in Alzheimer's models.

This paper uses linear regression with NMR and MD simulation data to determine ensemble structures of Alzheimer's Aβ monomers, revealing β-sheet and partially-helical conformations and their implications for amyloidogenesis.

This study develops genome-wide lncRNA-derived SSR markers for Dongxiang wild rice and validates their polymorphism and utility in genetic diversity analysis and breeding.

This study compares microbial community composition and nutrient fluxes in three aquaculture tail-water treatment systems using 16S rRNA sequencing and finds significant differences in bacterial diversity and nutrient cycling between the treatments.

This study compares the structure, function, and antigenicity of the SARS-CoV-2 Delta variant's spike protein with other variants, showing its enhanced membrane fusion and transmissibility.

This study shows high glucose increases TRAIL expression in CTLs, promoting beta cell apoptosis, and identifies metformin and vitamin D as synergistic therapies to mitigate this effect.

The paper identifies A-to-I RNA editing in SARS-CoV-2 by analyzing RNA-seq data and shows it affects viral characteristics and evolution.

This study identifies R2R3-MYB transcription factors in C. sinensis and links some to the regulation of galloylated catechin biosynthesis.

This study induces human adipose-derived mesenchymal stem cells into hepatocyte-like cells using small-molecule cocktails and growth factors, producing cells with mature phenotype and function.

The paper shows that SMC complexes can extrude DNA loops around large DNA-bound obstacles, suggesting a nontopological mechanism for loop extrusion.

This study identifies putative Golgi SAM transporters in Arabidopsis and shows their role in cell wall polysaccharide methylation and plant growth.

This study identifies sex-specific gain-of-function activity of p53 mutations in glioblastoma, showing mutation-specific differences in transforming astrocytes and altering gene expression patterns.

This study uses population genomic analyses to trace the evolutionary history of wall lizards in the Mediterranean Basin, revealing multiple lineages shaped by geological and climatic events.