W. Yang

This study compares cytokine, chemokine, and growth factor profiles in saliva and gingival crevicular fluid from healthy donors to determine which fluid is better for biomarker development.

This study shows peritumoral myofibroblasts suppress iCCA growth but promote metastasis through Vcam1-dependent mechanisms.

This paper introduces PRIME-Del, a prime editing method for precise genomic deletions, showing higher precision than CRISPR/Cas9 and enabling deletions with non-PAM junctions.

This study shows that HIV-1 signal peptide diversity affects Env glycosylation and antibody recognition of V1V2 epitopes.

The paper identifies nuclear STING partners that contribute to innate immune signaling by interacting with IRF3/7 transcription factors and enhancing antiviral responses.

This study isolates and identifies phosphate-solubilizing bacteria from soybean rhizosphere soil, finding strains that promote plant growth through organic acid secretion and indole acetic acid production.

This study reports two crystal structures of BCCIP, revealing structural similarities to GNATs and altered substrate-binding features, suggesting potential enzymatic activity and protein interactions.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

This study identifies an alternative P2 symmetry in chemoreceptor arrays of Treponema denticola, adapted to high membrane curvature, revealing new structural features and functional roles of CheA and CheW-CheR-like proteins.

The paper investigates how engineered chemoreceptor complexes stabilize a kinase-off state by sequestering kinase and substrate domains, using multiple biophysical techniques.

This study uses ribosome profiling to analyze SARS-CoV-2 and host mRNA translation in infected cells, finding that viral mRNAs are not more efficiently translated than host mRNAs and highlighting unique translational strategies.

This study shows that GSK3 inhibition improves growth and telomere function in DC patient-derived AT2 cells by enhancing Wnt signaling.

This study investigates how light intensity affects the coloration and structure of chimeric leaves in Ananas comosus var. bracteatus, finding that 50% shade optimizes growth and ornamental value.

This study shows that daily variable temperature accelerates flowering in Arabidopsis by increasing PIF4 and FT transcription while reducing FLC transcription, and constructs a gene regulatory network to model these interactions.

The paper reports cryoEM structures of DNA-PKcs in inactive and activated forms, revealing structural changes in HEAT repeats that drive kinase activation.

This study investigates how SARS-CoV-2 interacts with host antiviral pathways in respiratory and cardiac cells, finding it activates OAS-RNase L and PKR but not IFN, contrasting with MERS-CoV.

This study identifies humanized single domain antibodies that neutralize SARS-CoV-2 by targeting the spike receptor binding domain, showing improved activity when fused with the Fc region.

This paper introduces a new peptide stapling method using fluorine-thiol displacement reaction, showing improved stability, affinity, and cell permeability compared to traditional methods.

This study shows that the MNK1/2-eIF4E axis promotes immune suppression and metastasis in postpartum breast cancer by affecting both tumor and non-tumor cells.

The paper identifies public antibody clones in the human repertoire, including virus-neutralizing and anti-PD1 clones, and introduces a tool for analyzing Rep-seq data.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

The paper investigates how DNA sequence arrangements influence the structural organization of nucleoprotein complexes formed by FIS and H-NS in bacteria.

This study identifies distinct palmitoyl-protein signatures in large and small cancer-derived extracellular vesicles using a novel proteomic approach.

This study identifies the MNK1/2-eIF4E axis as a driver of melanoma phenotype switching, progression, and immunotherapy resistance, with potential therapeutic targeting.

This study identifies RIPK2 as a target for inhibiting prostate cancer metastasis by stabilizing c-Myc and shows its suppression reduces disease progression.

The paper introduces a method to improve pathogen detection in metagenomic data by correcting abundance estimates using species-specific genomic regions, enhancing sensitivity and specificity for low-abundance pathogens.

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

The paper identifies a germline non-coding GATA3 variant that alters chromatin topology and contributes to Ph-like ALL by activating an enhancer and reshaping 3D genome organization.

This study shows that hexaploidization in wheat enhances genetic recombination of the ancestral diploid genome, increasing evolutionary potential and aiding wheat's global spread.

This paper characterizes the kinetics of the radical-mediated C-C bond formation in MoaA, revealing a shunt pathway and determining the rate of the 3',8-cyclization step.