W. Zhu

The paper uses a hybrid in silico approach combining machine learning and pharmacophore modeling on NCATS screening data to identify novel inhibitors effective against multiple SARS-CoV-2 variants.

The paper identifies CD73-expressing memory T cells that decline with age and are functionally distinct, with potential interventions to improve immune memory in older adults.

This study shows that the N protein mutations R203K/G204R increase SARS-CoV-2 infectivity, replication, and virulence, contributing to its spread and disease severity.

This study verifies two SARS-CoV-2-encoded small RNAs and shows their role in promoting lung inflammation via cytokine and interferon pathways during infection.

This study uses iPSC-derived cardiomyocytes to show that mitochondrial oxidative stress and ER stress underlie early heart failure in HLHS patients.

This study uses optical tweezers and molecular dynamics to analyze the mechanical unfolding kinetics of yeast tRNAphe, revealing how structural features influence folding and the role of tertiary interactions in unfolding cooperativity.

This study identifies BcCrh1 as a cytoplasmic effector of Botrytis cinerea that induces plant cell death and defense responses during infection.

This study shows that MFG-E8 promotes Ang II-induced arterial inflammation and remodeling in aging, and its deficiency reduces these effects.

This study shows olanzapine induces NAFLD via the apoA5 pathway by increasing hepatic apoA5 protein and sortilin levels, with APOA5 knockdown reversing steatosis.

The paper identifies a chemical inhibitor of the CorC Mg2+ transporter and provides structural insights into its mechanism of action.

This paper identifies interfacial compatibility conflict as the cause of poor dentin bonding durability and shows that hydrophobizing the demineralized dentin matrix enhances adhesive infiltration and bonding strength.

This study identifies CTPS1 as a target for antiviral therapy by showing it suppresses interferon induction and promotes viral replication in SARS-CoV-2 infection.

The paper identifies two small proteins, MHA1 and MHA1L, that modulate ACD6 activity in Arabidopsis thaliana, affecting growth and defense trade-offs through calcium influx regulation.

This study compares the early host responses to SARS-CoV-2, SARS-CoV, and MERS-CoV infections using transcriptome analysis, revealing distinct patterns of cytokine and antiviral gene expression.

The paper shows the D614G mutation in SARS-CoV-2 Spike protein increases infectivity via ACE2 receptor binding.

This study identifies 23 SARS-CoV-2 3CLpro inhibitors through high-throughput screening, with several showing potent activity against viral infection.

This paper identifies six broad-spectrum inhibitors of SARS-CoV-2 and MERS-CoV spike-mediated cell entry through drug repurposing screens using pseudotyped particles.

This study shows that silicon nitride, aluminum nitride, and copper inactivate SARS-CoV-2 by >99% within one minute, with silicon nitride being the most effective without causing cell damage.

This paper describes the NCATS OpenData Portal, a platform for real-time sharing of drug screening data that accelerates translational research by enabling immediate access to large-scale datasets.

This study shows that Alk1 mutant endothelial cells expand clonally in mouse brain arteriovenous malformations (AVMs) and that BM-derived Alk1 mutant ECs can cause AVMs.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

The paper identifies six autophagy modulators that block SARS-CoV-2 cytopathic effects in Vero-E6 cells with EC50 values between 2.0 and 13 µM.

This study identifies FSTL1-expressing adipocyte progenitors as drivers of age-related brown adipose tissue involution in rabbits and humans, with loss of FSTL1 causing iBAT atrophy in mice.

The paper reports the structure of the ForT/PRPP complex and identifies residues critical for catalysis, proposing a mechanism for C-C bond formation in C-nucleotide antibiotic biosynthesis.

This study shows that inhibiting ARF6 protects mice from MDR Gram-negative bacterial infections by preserving vascular integrity.

The paper withdraws its manuscript due to invalid results and intends to revise the technical approach and interpretation.

The paper predicts nelfinavir as a potential inhibitor of 2019-nCov main protease using homology modeling, molecular docking, and binding free energy calculations.

This study investigates how urea and KI together denature protein structures through molecular dynamics simulations of TRPZIP4 in mixed solutions.

This study uses molecular dynamics simulations to show trehalose stabilizes protein structure by forming hydrogen bonds and replacing water molecules around the protein.

This paper describes the structure and mechanism of Can1, a cOA-activated CRISPR defence DNA nuclease, showing how cA4 binding activates its DNA nicking activity.