X. Zhang

This study evaluates the impact of BAFASAL, a bacteriophage preparation, on human gut microbiome composition and function using multi-omics analyses in an ex vivo setting.

This study uses molecular dynamics simulations to investigate how the L210F mutation in dOrai affects channel structure and activation, revealing conformational changes that may enable constitutive opening.

This study identifies genetic mutations in Zymomonas mobilis that cause self-flocculation by disrupting gene function and increasing c-di-GMP levels, enabling improved biomass recovery and productivity.

This study shows nitrates inhibit haustoria formation in parasitic plants by increasing abscisic acid levels, with effects observed in both facultative and obligate parasites.

This study shows that BiTE-secreting T cells outperform CAR T cells in killing glioma cells in vitro and in vivo, with enhanced cytotoxicity and tumor growth delay.

This study compares the efficacy of ancestral RBD, S1, and S-trimer vaccines against SARS-CoV-2 variants B.1.1.7, B.1.351, and B.1.617.1, finding that RBD and S-trimer induce higher neutralizing titers and maintain effectiveness against variants.

This study shows that the skeletal muscle circadian clock regulates titin splicing via RBM20, affecting sarcomere length and function.

This paper develops an artificial cytosol system using agarose-sucrose to create pH-sensitive liposomes that enhance drug delivery efficiency.

This paper introduces MLC-Seq, a method to sequence full-length tRNA isoforms and quantify RNA modifications, demonstrating its application on yeast and mouse tRNAs.

The paper introduces SerialFIB, an open-source software tool for automating cryo-FIB workflows, enabling customizable and efficient lamella preparation for cryo-electron tomography.

This study investigates how detergent charge affects protein orientation at the air-water interface in cryo-EM, finding that anionic detergents modify the interface charge to improve protein orientation distribution.

This study identifies the roles of histone acetyltransferases and deacetylases in the growth, virulence, stress resistance, and DNA repair of Alternaria alternata through gene deletion mutants.

This study identifies NS1-dengue virus protein's interaction with human HDL as a mechanism to trigger pro-inflammatory signals during infection.

The paper shows auxin's biphasic control of cell expansion coordinates hypocotyl elongation and apical hook formation in etiolated seedlings.

This study develops a far-red probe and microfluidic platform to image live erythrocyte membranes at the single-molecule level, enabling high-throughput super-resolution and tracking.

This study identifies a two-component system in UPEC that enhances bacterial survival under oxidative stress and promotes host cell pyroptosis via hemolysin.

This study investigates how Lsr2 represses and CmlR activates the chloramphenicol biosynthetic cluster in Streptomyces venezuelae, revealing their opposing roles in regulating antibiotic production.

This study investigates how mitochondrial Ca2+ uniporter (MCU) regulates interorganellar Ca2+ signaling and NFAT activation, showing that MCU-KO increases cytosolic Ca2+ despite reduced CRAC channel activity.

The paper reprograms human B cells to express HCDR3 regions of HIV-1 bNAbs, enabling diverse and physiologic repertoires that efficiently bind HIV-1 antigens.

The paper shows that inhibiting PLK1-dependent EBNA2 phosphorylation enhances EBNA2 activity, promoting lymphoma development in EBV-infected mice.

This study develops a method to sequence nearly full-length rRNA genes from environmental samples, achieving high accuracy and coverage in microbial community analysis.

This study identifies a sulfate-reducing bacterium that forms zero-valent sulfur through sulfide oxidation, highlighting a new pathway in the sulfur cycle.

The paper identifies Neanderthal introgression variants that influence gene expression in response to environmental perturbations and validates their regulatory function.

This study examines factors driving radiating diversification in Saussurea using Miocene to present data, finding increased diversification rates linked to climate fluctuations and adaptive traits.

This study examines the kinetic response of B-cell receptor (BCR) repertoire diversity and lineage expansion in non-human primates after TLR7/8 stimulation, finding that TLR7/8 selectively expands high-mutation, low-frequency IgKL lineages.

This study shows that influenza A and D viruses interfere with each other during coinfection based on the timing and order of infection, with proinflammatory responses playing a key role.

This study challenges the idea that hydrogen's antioxidant properties are its main biological function by showing limited hydroxyl radical scavenging and suggesting alternative mechanisms.

The paper investigates how different GLP-1R agonists affect G protein activation kinetics through structural and functional analyses.

The paper shows the N501Y spike mutation in SARS-CoV-2 enhances viral transmission in hamsters and human airway cells by increasing receptor binding affinity.

This study identifies additional ORFs in geminiviral genomes that encode small proteins with specific subcellular localizations and virulence functions.