X. Zheng

This study shows that combining fecal microbiota transplantation with anti-PD-1 therapy improves survival and tumor control in mice, with specific gut bacteria and metabolites contributing to the enhanced efficacy.

This study develops a sequence-based functional metagenomics approach to discover novel CopA genes in environmental microbiomes, identifying 175 new sequences with functional validation.

This study evaluates cause-specific survival in elderly differentiated thyroid cancer patients comparing surgical treatment vs. non-surgical management and the impact of RAI-131 therapy.

The paper identifies and deletes 19 Myb genes in Magnaporthe oryzae, finds most are expressed during infection, and identifies co-regulated groups with potential roles in pathogenicity.

The paper tests neutralization activity of sera from convalescents and vaccine recipients against Omicron, finding that vaccines maintain better neutralization than convalescents.

This study investigates how multiple global change drivers affect microbial communities in aquatic microcosms, finding that combined effects vary with temperature and driver number but not ecological organization level.

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

This study identifies multiple SARS-CoV-2 receptors, including ASGR1 and KREMEN1, which enable virus entry and correlate with multi-organ tropism and clinical symptoms.

The paper compares the turnover rates of CMV-specific CD8+ T-cells to memory phenotype CD8+ T-cells, finding they are similar regardless of response magnitude.

This study identifies natural killer-like B cells as pathogenic in rheumatoid arthritis by promoting Th17 differentiation and disease severity.

This study shows that Esm-1 reduces albuminuria and podocyte injury in diabetic mice, possibly through inhibiting interferon signaling.

The paper develops a small molecule for imaging immune cell activity in cancer immunotherapies and demonstrates its utility in predicting treatment outcomes.

The paper identifies IAP inhibitors as sensitizers that restore immune response in LKB1-mutant lung cancer by reactivating the STING pathway and enhancing immune infiltration.

This study shows that a single amino acid substitution in mouse protamine 1 disrupts DNA packaging and causes infertility by altering protein function and developmental outcomes.

This study examines how seasonal climate changes in Guangzhou affect Aedes albopictus development and its susceptibility to DENV-2, finding that mosquitoes can still transmit the virus in winter.

This paper designs a trimeric RBD vaccine candidate with mutations from multiple SARS-CoV-2 strains, showing broad neutralization against variants including Beta and Kappa.

This study shows that hyperglycemia represses HIF-1, leading to increased mitochondrial ROS production and renal injury in diabetes, which can be mitigated by restoring HIF-1 function.

OsciDrop generates size-tunable, monodisperse droplets on demand without microfabrication, enabling chip-free droplet assays for applications like virus quantification.

The study compares antibody responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that symptomatic individuals maintain higher and longer-lasting IgG and neutralizing capacities.

This paper develops a method to create 3D vascularized tissues using bioprinting and surgical anastomosis, showing improved viability and functionality in liver-like constructs.

This study shows that saturated fatty acids reduce β-cell lipid droplets by destabilizing FIT2, leading to ER stress and diabetes, while FIT2 overexpression protects against these effects.

This study shows that activating KLF2 reduces endothelial dysfunction in COVID-19 by decreasing monocyte adhesion and inflammation.

This study identifies and characterizes AnHSD, a novel homoserine dehydrogenase from Arthrobacter nicotinovorans that exhibits high oxidation activity for L-homoserine, suggesting its role in bacterial catabolism.

This study shows that Lkb1 is essential for maintaining vascular smooth muscle cell (VSMC) identity and function in mice, as its deletion leads to vascular abnormalities and aneurysm formation.

This study shows that PPARD promotes pancreatic ductal adenocarcinoma in mutant Kras mice on high-fat diets, and its inhibition could be a therapeutic strategy.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

This study identifies immune markers, including HLA-DR and CTLA-4 expression on CD4 T cells, that predict HBsAg loss in chronic hepatitis B patients.

This study shows that SARS-CoV-2-specific T cell memory persists for at least 9 months in most convalescent COVID-19 individuals, with some responses lasting longer.

This paper identifies a novel allele of the chromogen gene C from wild rice that regulates anthocyanin biosynthesis differently in indica and japonica subspecies.