Y. Chen

This study determines the structures of human ABCC4 in apo and complexed forms, revealing its role in exporting platelet agonists and inhibitors, and identifying a pocket for drug design.

The paper studies fibroblast organization and proliferation on substrates with topological defects using simulation and experiment, finding that division rates depend on cell area and aspect ratio.

This study reports the cryo-EM structure of MRGPRX1 bound to an agonist, revealing its activation mechanism and guiding the design of specific modulators for itch and pain treatment.

This study identifies LjPup1 as a cytokinin exporter in root nodules that coordinates shoot growth with nitrogen fixation by exporting active cytokinins.

This study develops a mathematical model to explain how Myxococcus xanthus uses mechanosensing during gliding motility to coordinate cell reversal frequency and multicellular pattern formation.

This study identifies 18 laccase genes in Hypsizygus marmoreus, analyzes their genomic distribution, evolution, and expression patterns, and links specific genes to lignin degradation and fruiting body formation.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

This study shows that MC1R agonist reduces scarring and improves healing in a chronic wound model by enhancing angiogenesis, lymphangiogenesis, and reducing inflammation.

The paper isolates and characterizes a novel lytic vibriophage, R16F, which shows potential as a biocontrol agent against V. parahaemolyticus due to its specificity and lack of virulence factors.

This study optimizes protein extraction methods for human sperm and investigates antibiotic effects on sperm proteome, finding increased concentration and malformed sperm with altered proteome expression.

This study uses a computational model to show that ventricular systolic function affects thrombus formation after EVAR, with specific correlations identified.

This study identifies OsCAX2 as a key gene for cadmium tolerance and accumulation in rice by promoting vacuolar sequestration, reducing grain cadmium levels by over 70%.

This study shows that pyruvate-conjugated PEGylated liposomes enhance uptake in retinal photoreceptors, reducing cell death in degeneration models compared to free drugs.

This study uses mid-infrared spectra of milk to establish models for assessing mammalian evolutionary relationships and genetic distances with high accuracy.

This paper demonstrates that planarians can navigate to a previously recognized location in a new maze, indicating they have spatial localization ability.

The paper establishes a stable human cell line as a reference for transcriptomic and proteomic studies, showing consistent results across generations and platforms.

This study identifies ESCRT-III homologs in magnetotactic bacteria, showing their role in membrane remodeling and multicellular morphogenesis through genomic and imaging analyses.

This study shows that oral nanoplastic exposure in mice leads to gut macrophage activation and IL-1β production, which affects brain function by causing microglial activation and cognitive decline.

The paper was withdrawn due to duplicate posting and is no longer available for citation.

The paper identifies an alternative pathway for malonyl-CoA production using oxaloacetate dehydrogenase in Streptomyces, enabling efficient bioproduction of malonyl-CoA-derived chemicals in E. coli.

The paper designs and characterizes a protein fold switching network where single amino acid substitutions can switch fold and function in proteins.

The paper identifies Mj-NEROSs, an effector from root-knot nematodes, which suppresses plant immunity by interacting with ISP in plastids to reduce ROS production.

A low carbohydrate diet suppresses neuroendocrine tumor onset and progression by reducing insulin signaling and PI3K-Akt-mTOR pathway activity in mouse models and correlates with better prognosis in patients.

This study describes a new saurosphargid species from the Early Triassic of South China and presents a phylogenetic analysis clarifying the relationships of sauropterygians and their evolutionary history.

The paper investigates the correlation between skin and musk glands in Chinese forest musk deer, finding strong gene expression overlap and roles for Sox9, Caveolin1, and AR in both tissues.

The paper analyzes divorce rates in birds using phylogenetic methods and finds male promiscuity and migration distance correlate with higher divorce rates.

This study shows that aquatic planarians can sense humidity and use this ability to find water during drought by diving behavior.

This study shows IRE-1α regulates both necroptosis and pyroptosis in mice by modulating GSDMD activity, with implications for therapeutic targeting in tissue injuries.

This study maps the dynamic trajectories of intracellular gene transfers in Poaceae using a novel tool, revealing lineage-specific patterns and functional roles of nuclear organelle genes.

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.